M
Mario Niepel
Researcher at Harvard University
Publications - 63
Citations - 5246
Mario Niepel is an academic researcher from Harvard University. The author has contributed to research in topics: Signal transduction & PI3K/AKT/mTOR pathway. The author has an hindex of 30, co-authored 59 publications receiving 4351 citations. Previous affiliations of Mario Niepel include University of California, Riverside & University of California, Santa Cruz.
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The nuclear pore complex: bridging nuclear transport and gene regulation
TL;DR: The nuclear pore complex is emerging as an important regulator of gene expression through its influence on the internal architectural organization of the nucleus and its apparently extensive involvement in coordinating the seamless delivery of genetic information to the cytoplasmic protein synthesis machinery.
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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
TL;DR: GR metrics are shown to be superior to conventional metrics for assessing the effects of small molecule drugs in dividing cells and to improve the study of cell signaling and growth using small molecules and biologics and to facilitate the discovery of drug-response biomarkers and the identification of drugs effective against specific patient-derived tumor cells.
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Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
William W. Chen,Birgit Schoeberl,Paul J. Jasper,Mario Niepel,Ulrik B. Nielsen,Douglas A. Lauffenburger,Peter K. Sorger +6 more
TL;DR: Key system‐wide features of ErbB signaling arise from nonlinear interaction among signaling elements, the properties of which appear quite different in context and in isolation.
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Discovery of Potent and Selective Covalent Inhibitors of JNK
Tinghu Zhang,Francisco Inesta-Vaquera,Mario Niepel,Jianming Zhang,Scott B. Ficarro,Thomas Machleidt,Ting Xie,Jarrod A. Marto,Namdoo Kim,Taebo Sim,John D. Laughlin,HaJeung Park,Philip LoGrasso,Matthew P. Patricelli,Tyzoon K. Nomanbhoy,Peter K. Sorger,Dario R. Alessi,Nathanael S. Gray +17 more
TL;DR: JNK-IN-8 is a selective JNK inhibitor that inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue.
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Classic and contemporary approaches to modeling biochemical reactions
TL;DR: The concepts described in this review are likely to become important for a much broader community of cellular and molecular biologists attempting to understand the promise and challenges of "systems biology" as applied to biochemical mechanisms.