M
Mario Roederer
Researcher at National Institutes of Health
Publications - 439
Citations - 56340
Mario Roederer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 117, co-authored 406 publications receiving 50586 citations. Previous affiliations of Mario Roederer include Vaccine Research Center & Stanford University.
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Journal ArticleDOI
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells
Michael R. Betts,Martha Nason,Sadie M. West,Stephen C. De Rosa,Stephen A. Migueles,Jonathan Abraham,Michael M. Lederman,Jose M. Benito,Paul A. Goepfert,Mark Connors,Mario Roederer,Richard A. Koup +11 more
TL;DR: The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.
Journal ArticleDOI
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Xueling Wu,Zhi Yong Yang,Yuxing Li,Carl Magnus Hogerkorp,William R. Schief,Michael S. Seaman,Tongqing Zhou,Stephen D. Schmidt,Lan Wu,Ling Xu,Nancy S. Longo,Krisha McKee,Sijy O'Dell,Mark K. Louder,Diane Wycuff,Yu Feng,Martha Nason,Nicole A. Doria-Rose,Mark Connors,Peter D. Kwong,Mario Roederer,Richard T. Wyatt,Gary J. Nabel,John R. Mascola +23 more
TL;DR: Three broadly neutralizing antibodies are identified, isolated from an HIV-1–infected individual, that exhibited great breadth and potency of neutralization and were specific for the co-receptor CD4-binding site of the glycoprotein 120 (gp120), part of the viral Env spike.
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Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
Michael R. Betts,Jason M. Brenchley,David Price,Stephen C. De Rosa,Daniel C. Douek,Mario Roederer,Richard A. Koup +6 more
TL;DR: A novel technique to enumerate antigen-specific CD8+ T cells using a marker expressed on the cell surface following activation induced degranulation, a necessary precursor of cytolysis, and CD107-expressing CD8+, expressing cognate T cell receptors (TCR), is presented.
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A human memory T cell subset with stem cell-like properties
Luca Gattinoni,Enrico Lugli,Yun Ji,Zoltan Pos,Chrystal M. Paulos,Máire F. Quigley,Máire F. Quigley,Jorge R. Almeida,Emma Gostick,Zhiya Yu,Carmine Carpenito,Ena Wang,Daniel C. Douek,David Price,David Price,Carl H. June,Francesco M. Marincola,Mario Roederer,Nicholas P. Restifo +18 more
TL;DR: A long-lived human memory T cell population that has an enhanced capacity for self-renewal and a multipotent ability to derive central memory, effector memory and effector T cells is described.
Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TL;DR: The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.