M
Mariya Chhatriwala
Researcher at Wellcome Trust Sanger Institute
Publications - 13
Citations - 790
Mariya Chhatriwala is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cellular differentiation & Gene. The author has an hindex of 9, co-authored 12 publications receiving 562 citations. Previous affiliations of Mariya Chhatriwala include Wellcome Trust Centre for Stem Cell Research & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Anna S E Cuomo,Daniel D Seaton,Davis J. McCarthy,Davis J. McCarthy,Iker Martinez,Marc Jan Bonder,Marc Jan Bonder,Jose Garcia-Bernardo,Shradha Amatya,Pedro Madrigal,Abigail Isaacson,Florian Buettner,Andrew J Knights,Kedar Nath Natarajan,Kedar Nath Natarajan,Ludovic Vallier,Ludovic Vallier,John C. Marioni,John C. Marioni,John C. Marioni,Mariya Chhatriwala,Oliver Stegle,Oliver Stegle +22 more
TL;DR: Induced pluripotent stem cells from 125 donors are exploited to track gene expression changes and expression quantitative trait loci at single cell resolution during in vitro endoderm differentiation to identify molecular markers that are predictive of differentiation efficiency of individual lines.
Journal ArticleDOI
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
Inês Cebola,Santiago A. Rodríguez-Seguí,Candy H.-H. Cho,José Bessa,José Bessa,Meritxell Rovira,Mario Luengo,Mariya Chhatriwala,Andrew Berry,Joan Ponsa-Cobas,Miguel Angel Maestro,Rachel E. Jennings,Lorenzo Pasquali,Lorenzo Pasquali,Ignasi Moran,Natalia Castro,Neil A. Hanley,Neil A. Hanley,José Luis Gómez-Skarmeta,Ludovic Vallier,Ludovic Vallier,Jorge Ferrer,Jorge Ferrer +22 more
TL;DR: A central role is uncovered for TEAD and its coactivator YAP as signal-responsive regulators of multipotent pancreatic progenitors, and this work provides a resource for the study of embryonic development of the human pancreas.
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Induction of Novel Agonist Selectivity for the ADP-Activated P2Y1 Receptor Versus the ADP-Activated P2Y12 and P2Y13 Receptors by Conformational Constraint of an ADP Analog
Mariya Chhatriwala,R. Gnana Ravi,Roshni I. Patel,José L. Boyer,Kenneth A. Jacobson,T. Kendall Harden +5 more
TL;DR: The results provide the first demonstration of a high-affinity agonist that discriminates among the three ADP-activated P2Y receptors, and therefore, introduce a potentially important new pharmacological tool for delineation of the relative biological action of these three signaling proteins.
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The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
TL;DR: Structural and functional analyses of the N-terminal DH/PH cassette of Trio substantiate a general role for DH-associated PH domains in engaging Rho GTPases directly for efficient guanine nucleotide exchange and support a parsimonious explanation for the essentially invariant linkage between DH and PH domains.
Journal ArticleDOI
Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity
Stephanie M. Linker,Lara Urban,Stephen J. Clark,Mariya Chhatriwala,Shradha Amatya,Davis J. McCarthy,Ingo Ebersberger,Ludovic Vallier,Ludovic Vallier,Wolf Reik,Wolf Reik,Wolf Reik,Oliver Stegle,Oliver Stegle,Marc Jan Bonder +14 more
TL;DR: This study applies parallel DNA methylation and transcriptome sequencing to differentiating human induced pluripotent stem cells to characterize splicing variation (exon skipping) and its determinants and reveals a previously underappreciated link betweenDNA methylation variation and splicing.