M
Marjorie Cornejo Pontelli
Researcher at University of São Paulo
Publications - 29
Citations - 1753
Marjorie Cornejo Pontelli is an academic researcher from University of São Paulo. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 20 publications receiving 566 citations. Previous affiliations of Marjorie Cornejo Pontelli include Washington University in St. Louis.
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Journal ArticleDOI
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Flávio P. Veras,Marjorie Cornejo Pontelli,Camila Meirelles de Souza Silva,Juliana E Toller-Kawahisa,Mikhael de Lima,Daniele C. Nascimento,Ayda Henriques Schneider,Diego B. Caetite,Lucas Alves Tavares,Isadora Marques Paiva,Roberta Ribeiro Costa Rosales,David F. Colón,Ronaldo B. Martins,Italo A. Castro,Glaucia M. Almeida,Maria Isabel Fernandes Lopes,Maira N. Benatti,Letícia Pastorelli Bonjorno,Marcela C Giannini,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fernando Crivelenti Vilar,Rodrigo de Carvalho Santana,Valdes Roberto Bollela,Maria Auxiliadora-Martins,Marcos C. Borges,Carlos Henrique Miranda,Antonio Pazin-Filho,Luis Lamberti Pinto da Silva,Larissa D. Cunha,Dario S. Zamboni,Felipe Dal-Pizzol,Luiz O. Leiria,Li Siyuan,Sabrina Setembre Batah,Alexandre Todorovic Fabro,Thais Mauad,Marisa Dolhnikoff,Amaro Nunes Duarte-Neto,Paulo Hilário Nascimento Saldiva,Thiago M. Cunha,José C. Alves-Filho,Eurico Arruda,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha +45 more
TL;DR: It is described that SARS-CoV-2 triggers the release of ACE2-depended neutrophil extracellular traps (NETs) that mediate lung pathology, supporting the use of NETs inhibitors for COVID-19 treatment.
Journal ArticleDOI
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Tamara S Rodrigues,Keyla Santos Guedes de Sá,Adriene Y. Ishimoto,Amanda Becerra,Samuel L. Oliveira,Letícia Yamawaka de Almeida,Augusto V. Gonçalves,Debora B. Perucello,Warrison A. Andrade,Ricardo M. C. Castro,Flávio P. Veras,Juliana E Toller-Kawahisa,Daniele C. Nascimento,Mikhael Haruo Fernandes de Lima,Camila Meirelles de Souza Silva,Diego B. Caetite,Ronaldo B. Martins,Italo A. Castro,Marjorie Cornejo Pontelli,Fábio Cury de Barros,Fábio Cury de Barros,Natalia B. do Amaral,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria Isabel Fernandes Lopes,Rodrigo de Carvalho Santana,Fernando Crivelenti Vilar,Maria Auxiliadora-Martins,Rodrigo Luppino-Assad,Sérgio C. L. Almeida,Fabiola Reis de Oliveira,Sabrina Setembre Batah,Li Siyuan,Maira N. Benatti,Thiago M. Cunha,José C. Alves-Filho,Fernando Q. Cunha,Larissa D. Cunha,Fabiani Gai Frantz,Tiana Kohlsdorf,Alexandre Todorovic Fabro,Eurico Arruda,Renê Donizeti Ribeiro de Oliveira,Paulo Louzada-Junior,Dario S. Zamboni +44 more
TL;DR: This work shows that inflammasomes are activated in response to SARS-CoV-2 infection in vitro and in COVID-19 patients, contributing to the exacerbated inflammatory response, impacting disease progression and clinical outcome.
Journal ArticleDOI
Defining the risk of SARS-CoV-2 variants on immune protection
Marciela M. DeGrace,Elodie Ghedin,Matthew B. Frieman,Florian Krammer,Alba Grifoni,Arghavan Alisoltani,Galit Alter,Rama Rao Amara,Ralph S. Baric,Dan H. Barouch,Jesse D. Bloom,Louis-Marie Bloyet,Gaston Bonenfant,Adrianus C. M. Boon,Eli Boritz,Debbie L Bratt,Traci L. Bricker,Liliana L Brown,William Buchser,Juan Manuel Carreño,Liel Cohen-Lavi,Tamarand L. Darling,Meredith E. Davis-Gardner,Bethany L. Dearlove,Han Di,Meike Dittmann,Nicole A. Doria-Rose,Daniel C. Douek,Christian Drosten,Venkata Viswanadh Edara,Ali H. Ellebedy,Thomas P. Fabrizio,Guido Ferrari,William C. Florence,Ron A. M. Fouchier,John Franks,Adolfo García-Sastre,Adam Godzik,Ana S. Gonzalez-Reiche,Aubree Gordon,Bart L. Haagmans,Peter Halfmann,David D. Ho,Michael R. Holbrook,Yaoxing Huang,Sarah James,Lukasz Jaroszewski,Trushar Jeevan,Robert M. Johnson,Terry Jones,Astha Joshi,Yoshihiro Kawaoka,Lisa Kercher,Marion Koopmans,Bette T. Korber,Eilay Koren,Richard A. Koup,Eric B. LeGresley,Jacob E. Lemieux,Mariel J. Liebeskind,Zhuoming Li,Brandi Livingston,James Logue,Yang Luo,Adrian B. McDermott,M. Juliana McElrath,Victoria A. Meliopoulos,Vineet D. Menachery,David C. Montefiori,Barbara Mühlemann,Vincent J. Munster,Jennifer E. Munt,Manoj S. Nair,Antonia Netzl,Anna Maria Niewiadomska,Sijy O'Dell,Andrew Pekosz,Stanley Perlman,Marjorie Cornejo Pontelli,Barry Rockx,Morgane Rolland,Paul W. Rothlauf,Sinai Sacharen,Richard H. Scheuermann,R. Schmidt,Michael Schotsaert,Stacey Schultz-Cherry,Robert A. Seder,Mayya Sedova,Alessandro Sette,Reed S. Shabman,Xiaoying Shen,Pei Yong Shi,Maulik Shukla,Viviana Simon,Spencer Stumpf,Nancy J. Sullivan,Larissa B. Thackray,James Theiler,Paul G. Thomas,Sanja Trifkovic,Sina Türeli,Samuel Ashby Turner,Maria Vakaki,Harm van Bakel,Laura A. VanBlargan,Leah R. Vincent,Zachary S. Wallace,Liang Wang,Maple Wang,Pengfei Wang,Wei Wang,Scott C. Weaver,Richard J. Webby,Carol D. Weiss,David E. Wentworth,Stuart Weston,Sean P. J. Whelan,Bradley M. Whitener,S. H. Wilks,Xuping Xie,Baoling Ying,Hyejin Yoon,Bin Zhou,Tomer Hertz,Derek J. Smith,Michael S. Diamond,Diane J. Post,Mehul S. Suthar +128 more
TL;DR: The SARS-CoV-2 Assessment of Viral Evolution (SAVE) as mentioned in this paper was designed to provide a real-time risk assessment of SARS CoV2 variants that could potentially affect the transmission, virulence and resistance to infection-and vaccine-induced immunity.
Journal ArticleDOI
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
Fernanda Crunfli,Victor Corasolla Carregari,Flávio P. Veras,Lucas Scardua Silva,Mateus Henrique Nogueira,André Saraiva Leão Marcelo Antunes,Pedro Henrique Vendramini,Aline Gazzola Fragnani Valenca,Caroline Brandão-Teles,Giuliana S. Zuccoli,Guilherme Reis-de-Oliveira,Licia C. Silva-Costa,Verônica M. Saia-Cereda,Bradley J. Smith,Ana Campos Codo,Gabriela Fabiano de Souza,Stéfanie Primon Muraro,Pierina Lorencini Parise,Daniel A. Toledo-Teixeira,Ícaro Maia Santos de Castro,B. M. Melo,Glaucia M. Almeida,Egidi Mayara Silva Firmino,Isadora Marques Paiva,Bruna Manuella Souza Silva,Rafaela M. Guimarães,Niele D. Mendes,Raíssa L Ludwig,Gabriel Palermo Ruiz,Thiago L. Knittel,Gustavo Gastão Davanzo,Jaqueline Aline Gerhardt,Patrícia Brito Rodrigues,Julia Forato,Mariene Ribeiro Amorim,Natalia S Brunetti,M. C. Martini,Maira N. Benatti,Sabrina Setembre Batah,Li Siyuan,Rafael Batista João,ítalo Karmann Aventurato,Mariana Rabelo de Brito,Maria J. Mendes,B Da Costa,Marina K. M. Alvim,José Roberto da Silva Júnior,Lívia Liviane Damião,Iêda Maria P de Sousa,Elessandra D da Rocha,Solange Maria Gonçalves,Luiz H Lopes da Silva,Vanessa Bettini,Brunno Machado de Campos,Guilherme Ludwig,Lucas Alves Tavares,Marjorie Cornejo Pontelli,Rosa Maria Mendes Viana,Ronaldo B. Martins,André Schwambach Vieira,José C. Alves-Filho,Eurico Arruda,Guilherme G Podolsky-Gondim,Marcelo Volpon Santos,Luciano Neder,André Damasio,Stevens K. Rehen,Marco Aurélio Ramirez Vinolo,Carolina Demarchi Munhoz,Paulo Louzada-Junior,Renê Donizeti Ribeiro de Oliveira,Fernando Q. Cunha,Helder I. Nakaya,Thais Mauad,Amaro Nunes Duarte-Neto,Luiz Fernando Ferraz da Silva,Marisa Dolhnikoff,Paulo Hilário Nascimento Saldiva,Alessandro S. Farias,Fernando Cendes,Pedro M. Moraes-Vieira,Alexandre Todorovic Fabro,Adriano Sebollela,Jose Luis Proenca-Modena,Clarissa L. Yasuda,Marcelo A. Mori,Thiago M. Cunha,Daniel Martins-de-Souza +87 more
TL;DR: It is shown that astrocytes are susceptible to SARS-CoV-2 infection through a noncanonical mechanism that involves spike–NRP1 interaction and respond to the infection by remodeling energy metabolism, which in turn alters the levels of metabolites used to fuel neurons and support neurotransmitter synthesis.
Posted ContentDOI
Infection of human lymphomononuclear cells by SARS-CoV-2
Marjorie Cornejo Pontelli,Italo A. Castro,Ronaldo B. Martins,Flávio P. Veras,Leonardo La Serra,Daniele C. Nascimento,Ricardo S. Cardoso,Roberta Ribeiro Costa Rosales,Thais Martins de Lima,Juliano de Paula Souza,Diego B. Caetite,Mikhael Hf de Lima,Juliana T Kawahisa,Marcela C Giannini,Letícia Pastorelli Bonjorno,Maria I. F. Lopes,Sabrina Setembre Batah,Li Siyuan,Rodrigo Luppino Assad,Sergio Cl Almeida,Fabiola Reis Oliveira,Maira N. Benatti,Lorena Lf Pontes,Rodrigo de Carvalho Santana,Fernando C Villar,Maria Auxiliadora Martins,Thiago M. Cunha,Rodrigo T Calado,José C. Alves-Filho,Dario S. Zamboni,Alexandre Todorovic Fabro,Paulo Louzada-Junior,Rene Dr de Oliveira,Fernando Q. Cunha,Eurico Arruda +34 more
TL;DR: In this study, in vitro infection of whole PBMCs from healthy donors was productive of virus progeny and results revealed that monocytes, as well as B and T lymphocytes, are susceptible to SARS-CoV-2 active infection and viral replication was indicated by detection of double-stranded RNA.