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Mark A. Febbraio

Researcher at Monash University

Publications -  334
Citations -  37319

Mark A. Febbraio is an academic researcher from Monash University. The author has contributed to research in topics: Skeletal muscle & Insulin resistance. The author has an hindex of 102, co-authored 326 publications receiving 33017 citations. Previous affiliations of Mark A. Febbraio include The Heart Research Institute & University of Melbourne.

Papers
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Journal ArticleDOI

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Bente Klarlund Pedersen, +1 more
- 03 Apr 2012 - 
TL;DR: The finding that the muscle secretome consists of several hundred secreted peptides provides a conceptual basis and a whole new paradigm for understanding how muscles communicate with other organs, such as adipose tissue, liver, pancreas, bones and brain.
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Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

Bente Klarlund Pedersen, +1 more
- 01 Oct 2008 - 
TL;DR: This review focuses on the myokine IL-6, its regulation by exercise, its signaling pathways in skeletal muscle, and its role in metabolism in both health and disease.
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Muscle-derived interleukin-6: mechanisms for activation and possible biological roles

Mark A. Febbraio, +1 more
- 01 Sep 2002 - 
TL;DR: It appears that intramuscular IL‐6 is stimulated by complex signaling cascades initiated by both calcium (Ca2+) ‐dependent and ‐independent stimuli, and it also seems likely that skeletal muscle produces IL‐ 6 to aid in maintaining metabolic homeostasis during periods of altered metabolic demand such as muscular exercise or insulin stimulation.
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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Andrew L. Carey, +12 more
- 01 Oct 2006 - 
TL;DR: It is demonstrated that acute IL- 6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK.
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Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans.

Rebecca L. Starkie, +4 more
- 01 May 2003 - 
TL;DR: Physical exercise and rhIL‐6 infusion at physiological concentrations inhibit endotoxin‐induced TNF‐α production in humans and suggest that the mechanism include IL‐6, which is produced by and released from exercising muscles.