M
Mark A. Herman
Researcher at Duke University
Publications - 64
Citations - 4453
Mark A. Herman is an academic researcher from Duke University. The author has contributed to research in topics: Fructose & Internal medicine. The author has an hindex of 18, co-authored 49 publications receiving 3372 citations. Previous affiliations of Mark A. Herman include Durham University & Broad Institute.
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Journal ArticleDOI
A guide to analysis of mouse energy metabolism
Matthias H. Tschöp,John R. Speakman,John R. Speakman,Jonathan R.S. Arch,Johan Auwerx,Jens C. Brüning,Lawrence Chan,Robert H. Eckel,Robert V. Farese,Jose E. Galgani,Catherine Hambly,Mark A. Herman,Tamas L. Horvath,Barbara B. Kahn,Sara C. Kozma,Eleftheria Maratos-Flier,Timo D. Müller,Heike Münzberg,Paul T. Pfluger,Leona Plum,Marc L. Reitman,Kamal Rahmouni,Gerald I. Shulman,George Thomas,C. Ronald Kahn,Eric Ravussin +25 more
TL;DR: A consolidated view of the complexity and challenges of designing studies for measurement of energy metabolism in mouse models is presented, including a practical guide to the assessment of energy expenditure, energy intake and body composition and statistical analysis thereof.
Journal ArticleDOI
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects
Mark M. Yore,Ismail Syed,Pedro M. Moraes-Vieira,Tejia Zhang,Mark A. Herman,Edwin A. Homan,Rajesh T. Patel,Jennifer Lee,Shili Chen,Odile D. Peroni,Abha Dhaneshwar,Ann Hammarstedt,Ulf Smith,Timothy E. McGraw,Alan Saghatelian,Barbara B. Kahn +15 more
TL;DR: PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans, and are endogenous lipids with the potential to treat type 2 diabetes.
Journal ArticleDOI
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Mark A. Herman,Odile D. Peroni,Jorge Villoria,Michael R. Schön,Nada A. Abumrad,Matthias Blüher,Samuel Klein,Barbara B. Kahn +7 more
TL;DR: It is reported that adipose tissue GLUT4 regulates the expression of carbohydrate-responsive-element-binding protein (ChREBP; also known as MLXIPL), a transcriptional regulator of lipogenic and glycolytic genes, and adipose ChREBP is a major determinant of adipOSE tissue fatty acid synthesis and systemic insulin sensitivity.
Journal ArticleDOI
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
Mark A. Herman,Barbara B. Kahn +1 more
TL;DR: The roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing are reviewed, including insulin-resistant states including type 2 diabetes.
Journal ArticleDOI
Fructose metabolism and metabolic disease
TL;DR: The biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease are reviewed.