M
Mark A. Holmes
Researcher at University of Cambridge
Publications - 219
Citations - 9755
Mark A. Holmes is an academic researcher from University of Cambridge. The author has contributed to research in topics: SCCmec & Methicillin-resistant Staphylococcus aureus. The author has an hindex of 44, co-authored 203 publications receiving 8248 citations. Previous affiliations of Mark A. Holmes include Queen's University & Animal Health Trust.
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Journal ArticleDOI
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440
Karen E. Nelson,Christian Weinel,Ian T. Paulsen,Robert J. Dodson,H. Hilbert,V. A. P. Martins Dos Santos,Derrick E. Fouts,Steven R. Gill,Mihai Pop,Mark A. Holmes,Lauren M. Brinkac,Maureen J. Beanan,Robert T. DeBoy,Sean C. Daugherty,James F. Kolonay,Ramana Madupu,William C. Nelson,Owen White,Jeremy Peterson,Hoda Khouri,Ioana R. Hance,P. Chris Lee,Erik Holtzapple,David J. Scanlan,Kevin Tran,A. Moazzez,T. Utterback,M. Rizzo,K. Lee,Daniel S. Kosack,D. Moestl,H. Wedler,J. Lauber,Diana Stjepandic,Jörg D. Hoheisel,M. Straetz,Sabina Heim,C. Kiewitz,Jonathan A. Eisen,Kenneth N. Timmis,A. Düsterhöft,Burkhard Tümmler,Claire M. Fraser +42 more
TL;DR: Pseudomonas putida is a metabolically versatile saprophytic soil bacterium that has been certified as a biosafety host for the cloning of foreign genes.
Journal ArticleDOI
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Laura García-Álvarez,Matthew T. G. Holden,Heather Lindsay,Cerian R. Webb,Derek F. J. Brown,Martin D. Curran,Enid Walpole,Karen Brooks,Derek Pickard,Christopher Teale,Julian Parkhill,Stephen D. Bentley,Giles Edwards,E Kirsty Girvan,Angela M. Kearns,Bruno Pichon,Robert Hill,Anders Rhod Larsen,Robert Skov,Sharon J. Peacock,Duncan J. Maskell,Mark A. Holmes +21 more
TL;DR: The discovery of a strain of S aureus isolated from bulk milk that was phenotypically resistant to meticillin but tested negative for the mecA gene is reported and new diagnostic guidelines for the detection of MRSA should consider the inclusion of tests for mecALGA251.
Journal ArticleDOI
The emergence of mecC methicillin-resistant Staphylococcus aureus.
TL;DR: A novel mecA homologue, mecC, confers methamphetamineicillin resistance to methicillin-resistant Staphylococcus aureus (MRSA) and may pose a zoonotic risk to humans.
Journal ArticleDOI
Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecALGA251
Marc Stegger,Paal Skytt Andersen,Angela M. Kearns,Bruno Pichon,Mark A. Holmes,Giles Edwards,Frédéric Laurent,Christopher Teale,Robert Skov,Anders Rhod Larsen +9 more
TL;DR: Over a 2-month period, 12 new MRSA cases caused by isolates carrying mecA(LGA251) were identified, emphasizing the clinical importance of testing for these new MR SA isolates.
Journal ArticleDOI
Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation
TL;DR: Airway T-lymphocytes and airway epithelial cells (AEC) show an increased likelihood of undergoing apoptosis in COPD and if this was related to smoking and continued excess apoptosis after smoking cessation may offer a new target for therapeutic interventions.