M
Mark A. Pershouse
Researcher at University of Montana
Publications - 38
Citations - 4051
Mark A. Pershouse is an academic researcher from University of Montana. The author has contributed to research in topics: Gene & Tumor suppressor gene. The author has an hindex of 14, co-authored 38 publications receiving 3946 citations. Previous affiliations of Mark A. Pershouse include University of Texas MD Anderson Cancer Center & University of Texas at Austin.
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Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
David H. F. Teng,Rong Hu,Huai Lin,Thaylon Davis,Diana Iliev,Cheryl Frye,Brad Swedlund,Kipp L. Hansen,Vickie L. Vinson,Kathryn L. Gumpper,Lee M. Ellis,Adel K. El-Naggar,Marsha L. Frazier,Samar A. Jasser,Lauren A. Langford,Jeffrey E. Lee,Gordon B. Mills,Mark A. Pershouse,Raphael E. Pollack,Carmen Tornos,Patricia Troncoso,W. K. Alfred Yung,Gregory H. Fujii,Amy E. Berson,Robert Bookstein,Joseph B. Bolen,Scan V. Tavtigian,Peter A. Steck +27 more
TL;DR: The occurrence of inactivating MMAC1 alterations in multiple human cancer types is supported by data supported by the high frequency of 10q allelic loss reported for many cancers.
Journal Article
Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance.
Huai Lin,Melissa L. Bondy,Lauren A. Langford,Kenneth R. Hess,George L. Delclos,Xifeng Wu,Wenyaw Chan,Mark A. Pershouse,W. K. Alfred Yung,Peter A. Steck +9 more
TL;DR: The results suggest that the DMBT1 gene may be involved early in the oncogenesis of gliomas, whereas alterations in the MMAC/PTEN gene might be a late event in theOncogenesis related to progression ofgliomas and provide a significant prognostic marker for patient survival.
Journal ArticleDOI
Two tumor suppressive loci on chromosome 10 involved in human glioblastomas
TL;DR: The results implicate the presence of two independent phenotypically suppressive regions on chromosome 10 (10pter‐q11 and 10q24‐q26) that are involved in glioma progression.
Journal ArticleDOI
Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma.
TL;DR: Results indicate that alterations of chromosome 4 regions are associated with HNSCC tumorigenesis and further localizes the regions that may harbor tumor suppressor genes.