M
Mark Blades
Researcher at Queen Mary University of London
Publications - 8
Citations - 978
Mark Blades is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Arthritis & Follicular dendritic cells. The author has an hindex of 6, co-authored 8 publications receiving 911 citations. Previous affiliations of Mark Blades include King's College London.
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Journal ArticleDOI
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Frances Humby,Michele Bombardieri,Antonio Manzo,Stephen Kelly,Mark Blades,Bruce Kirkham,Jo Spencer,Costantino Pitzalis +7 more
TL;DR: It is demonstrated that FDC+ follicular units invariably express AID and are surrounded by ACPA-producing plasma cells, providing strong evidence that ectopic lymphoid structures in the RA synovium are functional and support autoantibody production.
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Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome
Francesca Barone,Michele Bombardieri,Antonio Manzo,Mark Blades,Peter Morgan,Stephen Challacombe,Guido Valesini,Costantino Pitzalis +7 more
TL;DR: The acquisition of lymphoid features byinflammatory foci in SS is critically associated with the enlargement of the inflammatory foci and with the expression of CXCL13 and CCL21 within the infiltrate, but is not associated with their expression by epithelial cells.
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Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate.
Michele Bombardieri,Francesca Barone,V. Pittoni,Cristiano Alessandri,Paola Conigliaro,Mark Blades,Roberta Priori,Iain B. McInnes,Guido Valesini,Costantino Pitzalis +9 more
TL;DR: This study provides the first evidence of increased circulating levels and salivary gland expression of IL-18 in SS, suggesting an important contribution of this cytokine to the modulation of immune inflammatory pathways in this condition.
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Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model
Mary Connolly,Alessandra Marrelli,Mark Blades,J. McCormick,Paola Maderna,Catherine Godson,Ronan H Mullan,Oliver FitzGerald,Barry Bresnihan,Costantino Pitzalis,Douglas J. Veale,Ursula Fearon +11 more
TL;DR: In the RA synovial/SCID mouse chimera model, it is demonstrated for the first time in vivo that A-SAA directly induces monocyte migration from the murine circulation into RAsynovial grafts, synovIAL cell proliferation, and angiogenesis critical to RA pathogenesis.
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The role of substance P in microvascular responses in murine joint inflammation
Julie Keeble,Mark Blades,Costantino Pitzalis,Fransisco Airton Castro da Rocha,Susan D. Brain +4 more
TL;DR: Novel techniques are used in WT and NK1 knockout mice to show that SP can modulate vascular tone and permeability in the inflamed joint via activation of the NK1 receptor and that SP‐induced responses are more pronounced where pre‐existing inflammation is present.