Mark C. Pohlman

TL;DR: A strategy for whole-body rehabilitation-consisting of interruption of sedation and physical and occupational therapy in the earliest days of critical illness-was safe and well tolerated, and resulted in better functional outcomes at hospital discharge, a shorter duration of delirium, and more ventilator-free days compared with standard care.

TL;DR: Early physical and occupational therapy is feasible from the onset of mechanical ventilation despite high illness acuity and presence of life support devices, and adverse events related to this intervention are uncommon.

TL;DR: The finding that most subjects exhibited preserved, but phase delayed, excretion of aMT6s suggests that the circadian pacemaker of such patients may be free-running, and the circadian rhythms of patients receiving mechanical ventilation and intravenous sedation exhibit pronounced temporal disorganization.

TL;DR: Set tidal volume has a strong influence on frequency of stacked breaths and result in volumes substantially above the set tidal volume in patients treated with low tidal volume ventilation for acute lung injury.