https://yunus.hacettepe.edu.tr/~damlacetin/kmu407/index_dosyalar/4.%20makale.pdf

Biodegradable polymers as biomaterials

The return of a forgotten polymer—Polycaprolactone in the 21st century

s, and 360 patents, and edited 12 books. He has also received over 80 major awards including the Gairdner Foundation International Award, Lemelson-MIT prize, ACS’s Applied Polymer Science and Polymer Chemistry Awards, AICHE’s Professional Progress, Bioengineering, Walker and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine of the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and the National Academy of Sciences. He is the only active member of all three National Academies. Kevin Shakesheff was born in Ashington, Northumberland, U.K., in 1969. He received his Bacheclor of Pharmacy degree from the University of Nottingham in 1991 and a Ph.D. from the same institution in 1995. In 1996 he became a NATO Postdoctoral Fellow at MIT, Department of Chemical Engineering. He is currently an EPSRC Advanced Fellow at the School of Pharmaceutical Sciences, The University of Nottingham. His research group investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering. 3182 Chemical Reviews, 1999, Vol. 99, No. 11 Uhrich et al.

Polymeric Systems for Controlled Drug Release

Biodegradation and biocompatibility of PLA and PLGA microspheres

The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.

Reviews the properties, synthesis, and formulations of a number of well studied polymers increasingly being used in site-specific or systematic administration of pharmaceutical agents. For each of the polymers, discusses the background; chemistry and synthesis; the formulation of microcapsules, solv

/pdf/biodegradable-polymers-as-drug-delivery-systems-43th8shecb.pdf

Biodegradable polymers as drug delivery systems

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.

Formulations and methods for providing prolonged local anesthesia

BackgroundBiodegradable microspheres are a useful method of drug delivery because they are both injectable and biodegradable, eliminating the need for surgical implantation or removal. Previous work has characterized implantable preparations of local anesthetics in polymer pellets for prolonged regi

Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres.

BackgroundPrevious work showed that incorporation of dexamethasone (0.05 weight/weight percentage) into bupivacaine microspheres prolonged blockade by eight to 13 times compared with that produced by bupivacaine microspheres alone. The determinants of dexamethasone's block-prolonging effect were exa

Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres

Poly(anhydrides) proposed for use as vehicles for controlled drug delivery were administered subcutaneously in Sprague-Dawley rats at two dosage levels (800 mg/kg rat and 2400 mg/kg rat) for a period of eight weeks. Biocompatibility was assessed using a number of methods. Thirty-six clinical chemistry and hematology parameters were monitored throughout the study. Blood values were statistically analyzed for any possible effects due to the implanted polymer. After 8 weeks, rats were sacrificed and complete necropsies were performed. Histological evaluations of 33 organ sites including heart, lung, liver, kidney, and brain were performed. In addition, subcutaneous implant sites were excised and examined both grossly and microscopically. Results from evaluations of blood chemistry and hematology data, organ analyses and local implant site analyses overall demonstrated that the poly(anhydride) biomaterial possessed excellent in vivo biocompatibility.

Mark Chasin

Papers

Biodegradable polymers as drug delivery systems

Formulations and methods for providing prolonged local anesthesia

Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres.

Glucocorticoids prolong rat sciatic nerve blockade in vivo from bupivacaine microspheres

Poly(anhydride) administration in high doses in vivo: studies of biocompatibility and toxicology.