M
Mark D'Ascenzo
Researcher at Hoffmann-La Roche
Publications - 19
Citations - 3133
Mark D'Ascenzo is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 17, co-authored 19 publications receiving 3014 citations. Previous affiliations of Mark D'Ascenzo include Cornell University & Boyce Thompson Institute for Plant Research.
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Journal ArticleDOI
The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000
C. Robin Buell,Vinita Joardar,Magdalen Lindeberg,Jeremy D. Selengut,Ian T. Paulsen,Michelle L. Gwinn,Robert J. Dodson,Robert T. DeBoy,A. Scott Durkin,James F. Kolonay,Ramana Madupu,Sean C. Daugherty,Lauren M. Brinkac,Maureen J. Beanan,Daniel H. Haft,William C. Nelson,Tanja M. Davidsen,Nikhat Zafar,Liwei Zhou,Jia Liu,Qiaoping Yuan,Hoda Khouri,Nadia Fedorova,Bao Tran,Daniel A. Russell,Kristi Berry,Teresa Utterback,Susan Van Aken,Tamara Feldblyum,Mark D'Ascenzo,Wen Ling Deng,Adela R. Ramos,James R. Alfano,Samuel W. Cartinhour,Arun K. Chatterjee,Terrence P. Delaney,Sondra G. Lazarowitz,Gregory B. Martin,David J. Schneider,Xiaoyan Tang,Carol L. Bender,Owen White,Claire M. Fraser,Alan Collmer +43 more
TL;DR: The complete genome sequence of the model bacterial pathogen Pseudomonas syringae pathovar tomato DC3000 (DC3000), which is pathogenic on tomato and Arabidopsis thaliana, is reported and 1,159 genes unique to DC3000 are revealed, of which 811 lack a known function.
Journal ArticleDOI
8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease.
Leila Choe,Mark D'Ascenzo,Norman R. Relkin,Darryl J. Pappin,Philip L. Ross,Brian L. Williamson,Steven R. Lunenburg Guertin,Patrick Pribil,Kelvin H. Lee +8 more
TL;DR: An 8‐plex version of an isobaric reagent for the quantitation of proteins using shotgun methods is presented and it is found that there are differences in considering peptide‐based observations versus protein-based observations from quantitative shotgun proteomics studies.
Journal ArticleDOI
Genomewide identification of Pseudomonas syringae pv. tomato DC3000 promoters controlled by the HrpL alternative sigma factor.
Derrick E. Fouts,Robert B. Abramovitch,James R. Alfano,Angela M. Baldo,C. Robin Buell,Samuel W. Cartinhour,Arun K. Chatterjee,Mark D'Ascenzo,Michelle L. Gwinn,Sondra G. Lazarowitz,Nai-Chun Lin,Gregory B. Martin,Amos H. Rehm,David J. Schneider,David J. Schneider,Karin V. van Dijk,Xiaoyan Tang,Alan Collmer +17 more
TL;DR: A draft sequence of DC3000 is developed and an iterative process involving computational and gene expression techniques to identify virulence-implicated genes downstream of HrpL-responsive promoters is used to identify genes involved in pathogenesis.
Journal ArticleDOI
The tomato transcription factor Pti4 regulates defense-related gene expression via GCC box and non-GCC box cis elements.
Suma Chakravarthy,Robert P. Tuori,Mark D'Ascenzo,Pierre R. Fobert,Charles Després,Gregory B. Martin,Gregory B. Martin +6 more
TL;DR: Serial analysis of gene expression (SAGE) was used to compare transcripts in wild-type and Pti4-expressing Arabidopsis plants and revealed 78 differentially abundant transcripts encoding defense-related proteins, protein kinases, ribosomal proteins, transporters, and two transcription factors (TFs).
Journal ArticleDOI
ESTs, cDNA microarrays, and gene expression profiling: tools for dissecting plant physiology and development.
Rob Alba,Zhangjun Fei,Paxton Payton,Yang Liu,Shanna Moore,Paul Debbie,Jonathan Cohn,Mark D'Ascenzo,Jeffrey S. Gordon,Jocelyn K. C. Rose,Gregory B. Martin,Gregory B. Martin,Steven D. Tanksley,Mondher Bouzayen,Molly Jahn,James J. Giovannoni,James J. Giovannoni +16 more
TL;DR: Details of approaches used by others and ourselves for gene expression profiling in plants with emphasis on cDNA microarrays are provided and discussion of both experimental design and downstream analysis are discussed.