M
Mark D. Biggin
Researcher at Lawrence Berkeley National Laboratory
Publications - 99
Citations - 11333
Mark D. Biggin is an academic researcher from Lawrence Berkeley National Laboratory. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 42, co-authored 99 publications receiving 10975 citations. Previous affiliations of Mark D. Biggin include University of Chicago & University of California, Irvine.
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Journal ArticleDOI
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
R. Baer,R. Baer,Alan T. Bankier,Mark D. Biggin,Prescott L. Deininger,Paul J. Farrell,Toby J. Gibson,Graham F. Hatfull,Graham S. Hudson,Sandra C. Satchwell,C. Séguin,C. Séguin,P. S. Tuffnell,Bart Barrell +13 more
TL;DR: The complete (172,282 base pairs) nucleotide sequence of the B95-8 strain of Epstein–Barr virus has been established using the dideoxynucleotide/M13 sequencing procedure.
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Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.
TL;DR: The use of deoxyadenosine 5'-(alpha-[35S]thio)triphosphate as the label incorporated in dideoxynucleotide sequence reactions increases the sharpness of the bands on an autoradiograph and so increases the resolution achieved.
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Genome-wide analysis of Polycomb targets in Drosophila melanogaster
Yuri B. Schwartz,Tatyana G. Kahn,David A. Nix,David A. Nix,Xiao Yong Li,Richard Bourgon,Mark D. Biggin,Vincenzo Pirrotta +7 more
TL;DR: The distribution of the PcG proteins PC, E(Z and PSC and of trimethylation of histone H3 Lys27 (me3K27) in the D. melanogaster genome is determined and the role of these proteins in development, differentiation and disease is determined.
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Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm.
Xiao-Yong Li,Stewart MacArthur,Richard Bourgon,David A. Nix,Daniel A. Pollard,Venky N. Iyer,Aaron Hechmer,Lisa Simirenko,Mark Stapleton,Cris L. Luengo Hendriks,Hou Cheng Chu,Nobuo Ogawa,William Inwood,Victor Sementchenko,Amy Beaton,Richard Weiszmann,Susan E. Celniker,David W. Knowles,Thomas R. Gingeras,Terence P. Speed,Michael B. Eisen,Mark D. Biggin +21 more
TL;DR: Surprisingly, for five of the six factors, their recognition sites are not unambiguously more constrained evolutionarily than the immediate flanking DNA, even in more highly bound and presumably functional regions, indicating that comparative DNA sequence analysis is limited in its ability to identify functional transcription factor targets.
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Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts.
Mark D. Biggin,Robert Tjian +1 more
TL;DR: In vitro analysis of factors that regulate the expression of the Ultrabithorax (Ubx) homeotic gene during embryogenesis should help in understanding how Ubx expression is regulated and provide insight into the processes determining cellular fates during development.