M
Mark E. Cooper
Researcher at University of Queensland
Publications - 1514
Citations - 141899
Mark E. Cooper is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 158, co-authored 1463 publications receiving 124887 citations. Previous affiliations of Mark E. Cooper include University of Cambridge & University of Adelaide.
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Journal ArticleDOI
Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade.
Fabrice Bonnet,Riccardo Candido,Robert M. Carey,David J. Casley,Leileata M. Russo,Tanya M. Osicka,Mark E. Cooper,Zemin Cao,Zemin Cao +8 more
TL;DR: It is demonstrated that renal expression of both AT1 and AT2 receptor was reduced in long-term diabetic SHRs and that blockade of the AT1 receptor had disparate effects on expression of angiotensin II receptor subtypes.
Journal ArticleDOI
Biosensor profiling of molecular interactions in pharmacology
TL;DR: Biosensors are used in areas that encompass almost all sectors of drug discovery, diagnostics and the life sciences, and novel biosensor applications are being developed for the predictive profiling of key pharmacokinetic parameters of a molecule.
Journal ArticleDOI
Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction.
de Haan Jb,Mark E. Cooper +1 more
TL;DR: A unifying hypothesis that increased glucose-mediated ROS leads to endothelial dysfunction as the underpinning causative event triggering accelerated micro- and macrovascular complications is explored and use of Gpx1-mimetics holds promise as a targeted antioxidant approach and an alternative adjunct therapy to reduce diabetic complications.
Journal ArticleDOI
Episodic arc-ophiolite emplacement and the growth of continental margins: Late accretion in the Northern Irish sector of the Grampian-Taconic orogeny
Steven P. Hollis,Stephen Roberts,Mark R. Cooper,Garth Earls,Richard Herrington,Daniel J. Condon,Mark E. Cooper,Sandy M. Archibald,Stephen J. Piercey +8 more
TL;DR: In this paper, three distinct phases of arc-ophiolite accretion have been recognized and correlated within the Tyrone Volcanic Group of Northern Ireland have allowed all three episodes to now be correlated into the British and Irish Caledonides.
Journal ArticleDOI
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.
Sih Min Tan,Mark Ziemann,Mark Ziemann,Vicki Thallas-Bonke,Matthew Snelson,Vinod Kumar,Adrienne Laskowski,Tuong-Vi Nguyen,Kevin Huynh,Michele V Clarke,Renata Libianto,Scott T. Baker,Alison Skene,David A. Power,Richard J MacIsaac,Richard J MacIsaac,Darren C. Henstridge,Rick A. Wetsel,Assam El-Osta,Peter J. Meikle,Scott Wilson,Scott Wilson,Josephine M. Forbes,Mark E. Cooper,Elif I Ekinci,Trent M. Woodruff,Melinda T. Coughlan,Melinda T. Coughlan +27 more
TL;DR: Evidence is provided for a pivotal role of the C5a/C5aR1 axis in propagating renal injury in the development of DKD by disrupting mitochondrial agility, thereby establishing a new immunometabolic signaling pathway in DKD.