Mark E. Cooper

TL;DR: In patients with type 2 diabetes and nephropathy, LVH is associated with significantly increased risk of CV events and the progression of kidney disease, and losartan treatment of patients with LVH decreased the CV as well as renal risk to a level similar to that of patients without LVH.

TL;DR: It is demonstrated that a high FTSW threshold corresponded with drought resistance observed in some modern maize germplasm, which can enable breeding work seeking to exploit this adaptive trait to improved drought tolerance in low threshold F TSW germ Plasm.

TL;DR: It is demonstrated that conditioning regimen-induced ATP release is a primary driver of MDSC dysfunction through ATP receptor (P2x7R) engagement and NLRP3 inflammasome activation and this findings inform future clinical trials that would use M DSC to decrease alloresponses in inflammatory environments.

TL;DR: This work used an in silico approach to design a new class of nontoxic antimicrobials for the bacteria-specific mechanosensitive ion channel of large conductance, MscL, and shows that one antimicrobial of this class, compound 10, is effective against methicillin-resistant Staphylococcus aureus with no cytotoxicity in human cell lines at the therapeutic concentrations.

TL;DR: Combination therapy has the additional benefit of requiring only low doses of AT(1) receptor blockade and ACEI to achieve superior renoprotective effects in this diabetic nephropathy model.