M
Mark E. Cooper
Researcher at University of Queensland
Publications - 1514
Citations - 141899
Mark E. Cooper is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 158, co-authored 1463 publications receiving 124887 citations. Previous affiliations of Mark E. Cooper include University of Cambridge & University of Adelaide.
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Journal ArticleDOI
Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.
Manohar Salla,Mark S. Butler,Ruby Pelingon,Geraldine Kaeslin,Daniel E. Croker,Janet C. Reid,Jong Min Baek,Paul V. Bernhardt,Elizabeth M. J. Gillam,Mark E. Cooper,Avril A. B. Robertson +10 more
TL;DR: MCC950 is an orally bioavailable small molecule inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome that exhibits remarkable activity in multiple models of inflammatory disease as mentioned in this paper.
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The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity
Darren C. Henstridge,Josephine M. Forbes,Sally A. Penfold,Melissa F. Formosa,Sonia L Dougherty,Anna Gasser,Maximilian de Courten,Mark E. Cooper,Bronwyn A. Kingwell,Barbora de Courten +9 more
TL;DR: A lower expression of HSP72 protein in human skeletal muscle was associated with increased adiposity and decreased insulin sensitivity in healthy individuals, consistent with rodent data suggesting that H SP72 stimulates fat oxidation with consequent reduction in fat storage and adiposity.
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Mesenteric vascular angiotensin‐converting enzyme is increased in experimental diabetes mellitus
TL;DR: Diabetes mellitus was induced by streptozotocin in male Wistar rats, and angiotensin‐converting enzyme measured in plasma and mesenteric vessels 3 weeks later.
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Efficient synthesis of anacardic acid analogues and their antibacterial activities
TL;DR: An efficient method for the synthesis of anacardic acid derivatives was explored, and a small set of salicylic acid variants synthesised retaining a constant hydrophobic element (a naphthyl tail).
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Amplification free detection of herpes simplex virus DNA.
TL;DR: The detection of a synthetic DNA sequence from Herpes Simplex Virus-1 within swine cerebrospinal fluid (CSF), using a sandwich-like, magnetic nanoparticle pull-down assay, which can be captured magnetically and detected by fluorescence.