Mark E. Cooper

TL;DR: The data support a role for increased activity of angiotensin converting enzyme as a mechanism for vascular hypertrophy, which may be involved in the pathogenesis of diabetic vasculopathy and nephropathy.

TL;DR: VSTx1, a well characterized ion-channel inhibitor that preferentially binds to anionic lipid mixtures, and AA139 an antimicrobial β-hairpin peptide with uncharacterised lipid binding properties, currently in pre-clinical development are investigated.

TL;DR: Investigating the potential of Adenylosuccinate synthetase as an antifungal drug target finds that loss of function results in adenine auxotrophy in C. neoformans, as well as complete loss of virulence in a murine model, validating AdSS as a promising antif fungus drug target and laying a foundation for future in silico and in vitro screens for novel antIFungal compounds.

TL;DR: In this paper, the authors used the Repetitive Behavior Scale−Revised questionnaire as a measure of repetitive motor behaviors, self-injurious behaviors, compulsions, insistence on sameness, and circumscribed interests.