M
Mark E. Cooper
Researcher at University of Queensland
Publications - 1514
Citations - 141899
Mark E. Cooper is an academic researcher from University of Queensland. The author has contributed to research in topics: Diabetes mellitus & Diabetic nephropathy. The author has an hindex of 158, co-authored 1463 publications receiving 124887 citations. Previous affiliations of Mark E. Cooper include University of Cambridge & University of Adelaide.
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Yield response of rice (Oryza sativa L.) genotypes to drought under rainfed lowlands. 2. Selection of drought resistant genotypes
TL;DR: The results indicate that with the use of irrigated-control and drought test environments, genotypes with drought resistance can be identified by using DRI or delay in flowering, however, selections will differ depending on the type of drought condition.
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Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b
Bo Wang,Jay C. Jha,Shinji Hagiwara,Aaron McClelland,Karin Jandeleit-Dahm,Merlin C. Thomas,Mark E. Cooper,Phillip Kantharidis +7 more
TL;DR: Let-7b microRNA represents a potential new target for the treatment of renal fibrosis in diabetic and non-diabetic nephropathy with the upregulation of TGFBR1.
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Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway
Vicki Thallas-Bonke,Carsten Lindschau,Bishoy Rizkalla,Leon A. Bach,Geoffrey Boner,Matthias Meier,Hermann Haller,Mark E. Cooper,Josephine M. Forbes +8 more
TL;DR: Findings implicate AGEs as important stimuli for the activation of PKC, particularly PKC-alpha, in the diabetic kidney, which can be directly inhibited by ALT-711.
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Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine.
Stephen M. Twigg,Zemin Cao,S. McLennan,Wendy C. Burns,Gail C Brammar,Josephine M. Forbes,Mark E. Cooper +6 more
TL;DR: It is postulated that the antifibrotic effects of AG in this animal model may be partially mediated by CTGF, based on the in vitro findings in mesangial cells linking AGEs to CTGF expression.
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Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes.
Mona Sedeek,Alex Gutsol,Augusto C. Montezano,Dylan Burger,Aurelie Nguyen Dinh Cat,Chris R. J. Kennedy,Kevin D. Burns,Mark E. Cooper,Karin Jandeleit-Dahm,Patrick Page,Cedric Szyndralewiez,Freddy Heitz,Richard L. Hébert,Rhian M. Touyz,Rhian M. Touyz +14 more
TL;DR: A renoprotective effect of the Nox1/4 inhibitor, possibly through reduced oxidative damage and decreased ERK1/2 activation is suggested, suggesting GKT136901-sensitive targets are involved in complications of diabetes rather than in the disease process.