Mark E. Cooper

TL;DR: It is demonstrated that increasing plasma MG to levels observed in diabetic mice either using an exogenous source or generated following inhibition, its primary clearance enzyme, glyoxalase-1, was able to increase vascular adhesion and augment atherogenesis in euglycemic apolipoprotein E knockout mice to a similar magnitude as that observed in hyperglycemic mice with diabetes.

TL;DR: It is suggested that VEGF expression is modulated by AT1 and AT2 receptors, thereby implicating angiotensin II receptor subtypes in retinal diseases such as diabetic retinopathy.

TL;DR: ACE inhibition may have a specific role in preventing diabetes-associated vascular hypertrophy, an important process in the genesis of micro- and macrovascular diabetic complications.

TL;DR: It is suggested that endogenous endothelin and EGF may play a role in diabetes-induced vascular hypertrophy and that mast cells may be pathogenetically involved in this process.

TL;DR: Losartan conferred significant renal benefits and was well tolerated in Asian patients with type 2 diabetes and clinical nephropathy, and baseline proteinuria and low Hb were strong predictors of risk of renal outcomes.