M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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Spectral Biclustering of Microarray Data: Coclustering Genes and Conditions
TL;DR: This work develops a method that simultaneously clusters genes and conditions, finding distinctive "checkerboard" patterns in matrices of gene expression data, if they exist, and applies it to a selection of publicly available cancer expression data sets.
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Subcellular localization of the yeast proteome
Anuj Kumar,Seema Agarwal,John A. Heyman,Sandra Matson,Matthew Heidtman,Stacy Piccirillo,Lara Umansky,Amar Drawid,Ronald Jansen,Yang Liu,Kei-Hoi Cheung,Perry L. Miller,Mark Gerstein,G. Shirleen Roeder,Michael Snyder +14 more
TL;DR: This study reports the first proteome-scale analysis of protein localization within any eukaryote, and presents experimentally derived localization data for 955 proteins of previously unknown function: nearly half of all functionally uncharacterized proteins in yeast.
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Defining functional DNA elements in the human genome
Manolis Kellis,Barbara J. Wold,Michael Snyder,Bradley E. Bernstein,Anshul Kundaje,Georgi K. Marinov,Lucas D. Ward,Ewan Birney,Gregory E. Crawford,Job Dekker,Ian Dunham,Laura Elnitski,Peggy J. Farnham,Elise A. Feingold,Mark Gerstein,Morgan C. Giddings,David M. Gilbert,Thomas R. Gingeras,Eric D. Green,Roderic Guigó,Tim Hubbard,Jim Kent,Jason D. Lieb,Richard M. Myers,Michael J. Pazin,Bing Ren,John A. Stamatoyannopoulos,Zhiping Weng,Kevin P. White,Ross C. Hardison +29 more
TL;DR: The strengths and limitations of biochemical, evolutionary, and genetic approaches for defining functional DNA segments, potential sources for the observed differences in estimated genomic coverage, and the biological implications of these discrepancies are reviewed.
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Comprehensive functional genomic resource and integrative model for the human brain
Daifeng Wang,Daifeng Wang,Shuang Liu,Jonathan Warrell,Hyejung Won,Xu Shi,Fabio C. P. Navarro,Declan Clarke,Mengting Gu,Prashant Emani,Yucheng T. Yang,Min Xu,Michael J. Gandal,Shaoke Lou,Jing Zhang,Jonathan J. Park,Chengfei Yan,Suhn K. Rhie,Kasidet Manakongtreecheep,Holly Zhou,Aparna Nathan,Mette A. Peters,Eugenio Mattei,Dominic Fitzgerald,Tonya M. Brunetti,Jill Moore,Yan Jiang,Kiran Girdhar,Gabriel E. Hoffman,Selim Kalayci,Zeynep H. Gümüş,Gregory E. Crawford,Panos Roussos,Schahram Akbarian,Andrew E. Jaffe,Kevin P. White,Zhiping Weng,Nenad Sestan,Daniel H. Geschwind,James A. Knowles,Mark Gerstein +40 more
TL;DR: The resource and integrative analyses have uncovered genomic elements and networks in the brain, which in turn have provided insight into the molecular mechanisms underlying psychiatric disorders.
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What is a gene, post-ENCODE? History and updated definition
Mark Gerstein,Joel Rozowsky,Deyou Zheng,Jiang Du,Jan O. Korbel,Olof Emanuelsson,Zhengdong D. Zhang,Sherman M. Weissman,Michael Snyder +8 more
TL;DR: This definition side-steps the complexities of regulation and transcription by removing the former altogether from the definition and arguing that final, functional gene products (rather than intermediate transcripts) should be used to group together entities associated with a single gene.