M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
Dorothee Pflueger,Stéphane Terry,Andrea Sboner,Lukas Habegger,Raquel Esgueva,Pei-Chun Lin,Maria A. Svensson,Naoki Kitabayashi,Benjamin J. Moss,Theresa Y. MacDonald,Xuhong Cao,Terrence R. Barrette,Ashutosh Tewari,Mark S. Chee,Arul M. Chinnaiyan,David S. Rickman,Francesca Demichelis,Mark Gerstein,Mark A. Rubin +18 more
TL;DR: Seven new cancer-specific gene fusions are discovered and characterized, two involving the ETS genes ETV1 and ERG, and four involving non-ETS genes such as CDKN1A, CD9, and IKBKB, genes known to exhibit key biological roles in cellular homeostasis or assumed to be critical in tumorigenesis of other tumor entities.
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TOS9 regulates white-opaque switching in Candida albicans.
Thyagarajan Srikantha,Anthony R. Borneman,Karla J. Daniels,Claude Pujol,Wei Wu,Michael Seringhaus,Mark Gerstein,Song Yi,Michael Snyder,David R. Soll +9 more
TL;DR: A model was developed for the regulation of spontaneous switching between the opaque state and the white state that includes stochastic changes of Tos9p levels above and below a threshold that induce changes in the chromatin state of an as-yet-unidentified switching locus.
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Pseudogenes in the ENCODE regions: Consensus annotation, analysis of transcription, and evolution
Deyou Zheng,Adam Frankish,Robert Baertsch,Philipp Kapranov,Alexandre Reymond,Alexandre Reymond,Siew Woh Choo,Yontao Lu,Stylianos E. Antonarakis,Michael Snyder,Yijun Ruan,Chia-Lin Wei,Thomas R. Gingeras,Roderic Guigó,Jennifer Harrow,Mark Gerstein +15 more
TL;DR: This work extensively examined the transcriptional activity of the ENCODE pseudogenes and performed systematic series of pseudogene-specific RACE analyses, demonstrating that at least a fifth of the 201 pseudogene are transcribed in one or more cell lines or tissues.
Journal ArticleDOI
Identification and Analysis of Over 2000 Ribosomal Protein Pseudogenes in the Human Genome
TL;DR: The large-scale distribution of RP pseudogenes throughout the genome appears to result, chiefly, from random insertions with the numbers on each chromosome, consequently, proportional to its size, with the highest density in GC-intermediate regions of the genome.
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Diverse Roles and Interactions of the SWI/SNF Chromatin Remodeling Complex Revealed Using Global Approaches
Ghia Euskirchen,Raymond K. Auerbach,Eugene Davidov,Tara A. Gianoulis,Guoneng Zhong,Joel Rozowsky,Nitin Bhardwaj,Mark Gerstein,Michael Snyder +8 more
TL;DR: The results from the ChIP and immunoprecipitation experiments suggest that SWI/SNF facilitates gene regulation and genome function more broadly and through a greater diversity of interactions than previously appreciated.