M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
Papers
More filters
Journal ArticleDOI
Genomic analysis of membrane protein families: abundance and conserved motifs
TL;DR: A genome-wide analysis on patterns of the classified polytopic membrane protein families was carried out and the distribution of conserved amino acids and motifs in the transmembrane helix regions in these families were analyzed.
Journal ArticleDOI
A resolution-sensitive procedure for comparing protein surfaces and its application to the comparison of antigen-combining sites
TL;DR: In this article, a method is presented for the rapid, objective and automatic comparison of selected parts of protein surfaces as a function of resolution using differences and correlations of Fourier coefficients.
Journal ArticleDOI
The Centers for Mendelian Genomics: a new large-scale initiative to identify the genes underlying rare Mendelian conditions.
Michael J. Bamshad,Jay Shendure,David Valle,Ada Hamosh,James R. Lupski,Richard A. Gibbs,Eric Boerwinkle,Eric Boerwinkle,Richard P. Lifton,Mark Gerstein,Murat Gunel,Shrikant Mane,Deborah A. Nickerson +12 more
TL;DR: Over the next few years and in collaboration with the global human genetics community, the CMGs hope to facilitate the identification of the genes underlying a very large fraction of all Mendelian disorders.
Journal ArticleDOI
The current excitement about copy-number variation: how it relates to gene duplications and protein families.
Jan O. Korbel,Philip M. Kim,Xueying Chen,Alexander E. Urban,Sherman M. Weissman,Michael Snyder,Mark Gerstein +6 more
TL;DR: CNVs tend to affect specific gene functional categories, such as those associated with environmental response, and are depleted in genes related to basic cellular processes, which means they occur more often at the periphery of the protein interaction network.
Journal ArticleDOI
Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping
Thomas Royce,Joel Rozowsky,Paul Bertone,Manoj P. Samanta,Viktor Stolc,Viktor Stolc,Sherman M. Weissman,Michael Snyder,Mark Gerstein +8 more
TL;DR: The informatics challenges arising in the analysis of tiling microarray experiments are introduced as open problems to the scientific community and initial approaches for the analysis are presented for this nascent technology.