M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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One thousand somatic SNVs per skin fibroblast cell set baseline of mosaic mutational load with patterns that suggest proliferative origin.
Alexej Abyzov,Alexej Abyzov,Livia Tomasini,Bo Zhou,Nikolaos Vasmatzis,Gianfilippo Coppola,Mariangela Amenduni,Reenal Pattni,Michael Wilson,Mark Gerstein,Sherman M. Weissman,Alexander E. Urban,Flora M. Vaccarino +12 more
TL;DR: A large degree of somatic mosaicism in healthy human tissues is revealed, which could be a characteristic of clonal cell selection, clonal expansion, or both, and de novo and cancer mutations to somatic mosaicicism are linked.
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Integrative database analysis in structural genomics.
TL;DR: An important aspect of structural genomics is connecting coordinate data with whole-genome information related to phylogenetic occurrence, protein function, gene expression, and protein–protein interactions.
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PubNet: a flexible system for visualizing literature derived networks
TL;DR: PubNet supports the creation of complex networks derived from the contents of individual citations, such as genes, proteins, Protein Data Bank IDs, Medical Subject Headings, and authors, allowing for graphical visualization, textual navigation, and topological analysis.
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Design optimization methods for genomic DNA tiling arrays
Paul Bertone,Valery Trifonov,Joel Rozowsky,Falk Schubert,Olof Emanuelsson,John E. Karro,Ming-Yang Kao,Michael Snyder,Mark Gerstein +8 more
TL;DR: A recent development in microarray research entails the unbiased coverage, or tiling, of genomic DNA for the large-scale identification of transcribed sequences and regulatory elements, and two algorithms for finding an optimal tile path composed of longer sequence tiles are developed.