M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
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Journal ArticleDOI
Gene inactivation and its implications for annotation in the era of personal genomics
Suganthi Balasubramanian,Lukas Habegger,Adam Frankish,Daniel G. MacArthur,Rachel A. Harte,Chris Tyler-Smith,Jennifer Harrow,Mark Gerstein +7 more
TL;DR: The extent of variation in gene and pseudogene numbers between individuals arising from inactivation events such as premature termination or aberrant splicing due to single-nucleotide polymorphisms is described.
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Measuring shifts in function and evolutionary opportunity using variability profiles: a case study of the globins.
Gavin J. P. Naylor,Mark Gerstein +1 more
TL;DR: The relationship between sequence variability and ``evolutionary opportunity'' is discussed and the utility of Maynard Smith's multidimensional evolutionary opportunity space metaphor is explored for exploring functional constraints, genetic redundancy, and the context dependency of the genotype-phenotype map.
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ACT: aggregation and correlation toolbox for analyses of genome tracks.
Justin Jee,Joel Rozowsky,Kevin Y. Yip,Lucas Lochovsky,Robert D. Bjornson,Guoneng Zhong,Zhengdong D. Zhang,Yutao Fu,Jie Wang,Zhiping Weng,Mark Gerstein +10 more
TL;DR: An efficient, multifaceted toolbox for analyzing continuous signal and discrete region tracks from high-throughput genomic experiments, such as RNA-seq or ChIP-chip signal profiles from the ENCODE and modENCODE projects, or lists of single nucleotide polymorphisms from the 1000 genomes project.
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Global Survey of Human T Leukemic Cells by Integrating Proteomics and Transcriptomics Profiling
Linfeng Wu,Sun-Il Hwang,Karim Rezaul,Long J. Lu,Long J. Lu,Viveka Mayya,Mark Gerstein,Jimmy K. Eng,Deborah H. Lundgren,David K. Han +9 more
TL;DR: This proteome landscape can serve as a useful platform for systems-level understanding of organelle composition and cellular functions in human T cells.
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Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome.
Zhaolei Zhang,Mark Gerstein +1 more
TL;DR: This study provides a catalogue of human MRP pseudogenes, which will be useful in the study of functional MRP genes and provides a molecular record of the evolution of these genes.