M
Mark Gerstein
Researcher at Yale University
Publications - 802
Citations - 172183
Mark Gerstein is an academic researcher from Yale University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 168, co-authored 751 publications receiving 149578 citations. Previous affiliations of Mark Gerstein include Rutgers University & Structural Genomics Consortium.
Papers
More filters
Journal ArticleDOI
Comparative analysis of genome tiling array data reveals many novel primate-specific functional RNAs in human.
TL;DR: The existence of potential primate-specific functional transcripts has demonstrated the limitation of previous genome comparison studies, which put too much emphasis on conservation between human and rodents and argues for the necessity of sequencing additional primate species to gain a better and more comprehensive understanding of the human genome.
Book ChapterDOI
Semantic Web Approach to Database Integration in the Life Sciences
Kei-Hoi Cheung,Andrew Smith,Kevin Y. Yip,Christopher J. O. Baker,Christopher J. O. Baker,Mark Gerstein +5 more
TL;DR: This chapter presents two use cases, namely YeastHub and LinkHub, which demonstrate how to use the latest RDF database technology to build data warehouses that facilitate integration of genomic/proteomic data and identifiers.
Journal ArticleDOI
Identification of Genes Critical for Resistance to Infection by West Nile Virus Using RNA-Seq Analysis
Feng Qian,Lisa Chung,Wei Zheng,Vincent M. Bruno,Roger P. Alexander,Zhong Wang,Xiaomei Wang,Sebastian Kurscheid,Hongyu Zhao,Erol Fikrig,Mark Gerstein,Michael Snyder,Ruth R. Montgomery +12 more
TL;DR: A high-throughput method based on a novel gene expression analysis, RNA-Seq, is used to give a global picture of differential gene expression by primary human macrophages of 10 healthy donors infected in vitro with WNV.
Journal ArticleDOI
What is the natural boundary of a protein in solution
Mark Gerstein,R. M. Lynden-Bell +1 more
TL;DR: A comparison of these 'normal' water simulations with a simulation of a simple, uncharged solvent highlights the importance of hydrogen bonding in structuring liquid water and further contrasts the molecular surface and the hydration surface.
Journal ArticleDOI
The DART classification of unannotated transcription within the ENCODE regions: Associating transcription with known and novel loci
Joel Rozowsky,Daniel E. Newburger,Fred Sayward,Jia Qian Wu,Greg Jordan,Jan O. Korbel,Ugrappa Nagalakshmi,Jin Yang,Deyou Zheng,Roderic Guigó,Thomas R. Gingeras,Sherman M. Weissman,Perry L. Miller,Michael Snyder,Mark Gerstein +14 more
TL;DR: This work uses a number of disparate features to classify the 6988 novel TARs-array expression profiles across cell lines and conditions, sequence composition, phylogenetic profiles (presence/absence of syntenic conservation across 17 species), and locations relative to genes.