M
Mark Helm
Researcher at University of Mainz
Publications - 213
Citations - 13164
Mark Helm is an academic researcher from University of Mainz. The author has contributed to research in topics: RNA & Transfer RNA. The author has an hindex of 51, co-authored 193 publications receiving 10413 citations. Previous affiliations of Mark Helm include California Institute of Technology & Centre national de la recherche scientifique.
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Journal ArticleDOI
MODOMICS: a database of RNA modification pathways. 2017 update.
Pietro Boccaletto,Magdalena A. Machnicka,Magdalena A. Machnicka,Elzbieta Purta,Pawel Piatkowski,Błażej Bagiński,Tomasz K Wirecki,de Crécy-Lagard,Robert L. Ross,Patrick A. Limbach,Annika Kotter,Mark Helm,Janusz M. Bujnicki,Janusz M. Bujnicki +13 more
TL;DR: In the current database version of MODOMICS, the following new features and data are included: extended mass spectrometry and liquid chromatography data for modified nucleosides; links between human tRNA sequences and MINTbase - a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments.
Journal ArticleDOI
MODOMICS: a database of RNA modification pathways—2013 update
Magdalena A. Machnicka,Kaja Milanowska,Okan Osman Oglou,Elzbieta Purta,Malgorzata Kurkowska,Anna Olchowik,Witold Januszewski,Sebastian Kalinowski,Stanislaw Dunin-Horkawicz,Kristian M. Rother,Mark Helm,Janusz M. Bujnicki,Henri Grosjean +12 more
TL;DR: New features are included: a census of human and yeast snoRNAs involved in RNA-guided RNA modification, a new section covering the 5′-end capping process, and a catalogue of ‘building blocks’ for chemical synthesis of a large variety of modified nucleosides.
Journal ArticleDOI
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
Matthias Schaefer,Tim Pollex,Katharina Hanna,Francesca Tuorto,Madeleine Meusburger,Madeleine Meusburger,Mark Helm,Mark Helm,Frank Lyko +8 more
TL;DR: Results uncover a novel biological function of Dnmt2-mediated tRNA methylation, and suggest a role for DnMT2 enzymes during the biogenesis of tRNA-derived small RNAs.
Journal ArticleDOI
Detecting RNA modifications in the epitranscriptome: predict and validate
Mark Helm,Yuri Motorin +1 more
TL;DR: The major developments in this field are outlined through a structured discussion of detection principles, advantages and drawbacks of new high-throughput methods are laid out, and conventional biophysical identification of modifications as meaningful ways for validation are presented.
Journal ArticleDOI
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.
Francesca Tuorto,Reinhard Liebers,Tanja Musch,Matthias Schaefer,Sarah Hofmann,Stefanie Kellner,Michaela Frye,Mark Helm,Georg Stoecklin,Frank Lyko +9 more
TL;DR: A biologically important function for cytosine-C5 tRNA methylation in mammals is established and it is suggested that this modification promotes mouse development by supporting protein synthesis.