M
Mark J. Manary
Researcher at Washington University in St. Louis
Publications - 267
Citations - 18264
Mark J. Manary is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Population & Malnutrition. The author has an hindex of 56, co-authored 244 publications receiving 15523 citations. Previous affiliations of Mark J. Manary include University of Health Sciences Antigua & University of Washington.
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Journal ArticleDOI
Human gut microbiome viewed across age and geography
Tanya Yatsunenko,Federico E. Rey,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Maria Gloria Dominguez-Bello,Monica Contreras,Magda Magris,Glida Hidalgo,Robert N. Baldassano,Andrey P. Anokhin,Andrew C. Heath,Barbara B. Warner,Jens Reeder,Justin Kuczynski,J. Gregory Caporaso,Catherine A. Lozupone,Christian L. Lauber,Jose C. Clemente,Dan Knights,Rob Knight,Jeffrey I. Gordon +22 more
TL;DR: The need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization is underscored, as distinctive features of the functional maturation of the gut microbiome are evident in early infancy as well as adulthood.
Journal ArticleDOI
Gut microbiomes of Malawian twin pairs discordant for kwashiorkor
Michelle I. Smith,Tanya Yatsunenko,Mark J. Manary,Mark J. Manary,Mark J. Manary,Indi Trehan,Indi Trehan,Rajhab S. Mkakosya,Jiye Cheng,Andrew L. Kau,Stephen S. Rich,Patrick Concannon,Josyf C. Mychaleckyj,Jie Liu,Eric R. Houpt,Jia V. Li,Elaine Holmes,Jeremy K. Nicholson,Dan Knights,Luke K. Ursell,Rob Knight,Jeffrey I. Gordon +21 more
TL;DR: The authors investigated the role of the gut microbiome in kwashiorkor, an enigmatic form of severe acute malnutrition that is the consequence of inadequate nutrient intake plus additional environmental insults, and found that RUTF produced a transient maturation of metabolic functions that regressed when administration of RUTF was stopped.
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Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children
Laura V. Blanton,Mark R. Charbonneau,Tarek Salih,Michael J. Barratt,Siddarth Venkatesh,Olga Ilkaveya,Sathish Subramanian,Mark J. Manary,Indi Trehan,Josh M Jorgensen,Yue-Mei Fan,Bernard Henrissat,Semen A. Leyn,Dmitry A. Rodionov,Andrei L. Osterman,Kenneth Maleta,Christopher B. Newgard,Per Ashorn,Kathryn G. Dewey,Jeffrey I. Gordon +19 more
TL;DR: These preclinical findings provide evidence that gut microbiota immaturity is causally related to childhood undernutrition and reveal that specific beneficial microbes could potentially be exploited to resolve undernutrition syndromes.
Journal ArticleDOI
Season of Conception in Rural Gambia Affects DNA Methylation at Putative Human Metastable Epialleles
Robert A. Waterland,Richard Kellermayer,Eleonora Laritsky,Pura Rayco-Solon,R. Alan Harris,Michael Travisano,Wenjuan Zhang,Maria S. Torskaya,Jiexin Zhang,Lanlan Shen,Mark J. Manary,Andrew M. Prentice +11 more
TL;DR: DNA methylation at MEs was elevated in individuals conceived during the nutritionally challenged rainy season, providing the first evidence of a permanent, systemic effect of periconceptional environment on human epigenotype.
Journal ArticleDOI
Phylogenetic Placement of Exact Amplicon Sequences Improves Associations with Clinical Information
Stefan Janssen,Daniel McDonald,Antonio Gonzalez,Jose A. Navas-Molina,Lingjing Jiang,Zhenjiang Zech Xu,Kevin Winker,Deborah M. Kado,Eric S. Orwoll,Mark J. Manary,Siavash Mirarab,Rob Knight +11 more
TL;DR: The SATé-enabled phylogenetic placement (SEPP) technique explicitly against 16S V4 sequence fragments is benchmarked and it is shown that it outperforms the conceptually problematic but often-used practice of reconstructing de novo phylogenies.