M
Mark J. Pallen
Researcher at University of East Anglia
Publications - 256
Citations - 18609
Mark J. Pallen is an academic researcher from University of East Anglia. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 71, co-authored 249 publications receiving 16985 citations. Previous affiliations of Mark J. Pallen include Norwich Research Park & University of Birmingham.
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Journal ArticleDOI
The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
Julian Parkhill,Brendan W. Wren,Karen Mungall,Julian M. Ketley,Carol Churcher,D. Basham,Tracey Chillingworth,Robert L. Davies,Theresa Feltwell,S. Holroyd,Kay Jagels,Andrey V. Karlyshev,Sharon Moule,Mark J. Pallen,Charles W. Penn,Michael A. Quail,Marie-Adèle Rajandream,Kim Rutherford,A. H. M. van Vliet,Sally Whitehead,Bart Barrell +20 more
TL;DR: The genome sequence of C. jejuni NCTC11168 is reported, finding short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function.
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Performance comparison of benchtop high-throughput sequencing platforms
Nicholas J. Loman,Raju Misra,Timothy J. Dallman,Chrystala Constantinidou,Saheer E. Gharbia,John Wain,John Wain,Mark J. Pallen +7 more
TL;DR: The performance of these instruments were compared by sequencing an isolate of Escherichia coli O104:H4, which caused an outbreak of food poisoning in Germany in 2011, and the MiSeq had the highest throughput per run and lowest error rates.
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A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
Stuart Knutton,Ilan Rosenshine,Mark J. Pallen,Israel Nisan,Bianca C. Neves,Bianca C. Neves,Christopher Bain,Carmel Wolff,Gordon Dougan,Gad Frankel +9 more
TL;DR: A novel EspA‐containing filamentous organelle is described that is present on the bacterial surface during the early stage of A/E lesion formation, forms a physical bridge between the bacterium and the infected eukaryotic cell surface and is required for the translocation of EspB into infected epithelial cells.
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Type VI secretion: a beginner's guide.
TL;DR: Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria and has been implicated in the translocation of a potential effector protein into eukaryotic cells by at least one organism (Vibrio cholerae).
Journal ArticleDOI
An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination
Toru Tobe,Scott A. Beatson,Scott A. Beatson,Hisaaki Taniguchi,Hiroyuki Abe,Christopher M. Bailey,Amanda Fivian,Rasha Younis,Sophie A. Matthews,Olivier Marchès,Gad Frankel,Gad Frankel,Tetsuya Hayashi,Mark J. Pallen +13 more
TL;DR: Binformatics and experimental approaches are exploited to establish that the effector repertoire in the Sakai strain of enterohemorrhagic E. coli (EHEC) O157:H7 is much larger than previously thought.