Mark L. Powell

TL;DR: The purpose of this report is to represent the progress in analytical methodologies over the last decade and assessment of the major agreements and issues discussed with regard to small molecules at both the conference and the workshop.

TL;DR: A direct-injection liquid chromatography-mass spectrometry-massSpectrometry (LC-MS-MS) method was developed and validated for the simultaneous quantitation in human plasma of the widely used cholesterol-lowering prodrug simvastatin and its in vivo generated active drug, simvastsatin acid.

TL;DR: A ternary-column on-line LC/MS/MS system with dual extraction columns used in parallel for purification and an analytical column for analysis that has successfully been used to develop and validate a positive ion electrospray LC/ MS/MS bioanalytical method for the quantitative determination of a guanidine-containing drug candidate in rat plasma.

TL;DR: The results showed that the two methods for post-dose human plasma sample analysis by high performance liquid chromatography with tandem mass spectrometry (LC/MS/MS) were equivalent in terms of total chromatographic run time, accuracy and precision.

TL;DR: A set of procedures to undertake with incurred samples are recommended, as soon as such samples are available, in order to establish the validity of an LC/MS/MS method for analyzing real-life samples.