M
Mark Mercola
Researcher at Cardiovascular Institute of the South
Publications - 219
Citations - 12607
Mark Mercola is an academic researcher from Cardiovascular Institute of the South. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 59, co-authored 201 publications receiving 11224 citations. Previous affiliations of Mark Mercola include University of California, Berkeley & Sanford-Burnham Institute for Medical Research.
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Wnt antagonism initiates cardiogenesis in Xenopus laevis
TL;DR: It is reported that the Wnt antagonists Dkk-1 and Crescent can induce heart formation in explants of ventral marginal zone mesoderm, and analysis of Wnt proteins expressed during gastrulation revealed that Wnt3A and Wnt8, but not Wnt5A or Wnt11, inhibited endogenous heart induction.
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Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
Ke Wei,Ke Wei,Vahid Serpooshan,Cecilia Hurtado,Cecilia Hurtado,Marta Diez-Cuñado,Marta Diez-Cuñado,Marta Diez-Cuñado,Mingming Zhao,Sonomi Maruyama,Wenhong Zhu,Wenhong Zhu,Giovanni Fajardo,Michela Noseda,Kazuto Nakamura,Xueying Tian,Qiaozhen Liu,Andrew Wang,Yuka Matsuura,Paul J. Bushway,Paul J. Bushway,Wenqing Cai,Wenqing Cai,Alex Savchenko,Alex Savchenko,Morteza Mahmoudi,Morteza Mahmoudi,Michael D. Schneider,Maurice J.B. van den Hoff,Manish J. Butte,Phillip C. Yang,Kenneth Walsh,Bin Zhou,Daniel Bernstein,Mark Mercola,Mark Mercola,Pilar Ruiz-Lozano +36 more
TL;DR: The data suggest that the loss of epicardial FSTL1 is a maladaptive response to injury, and that its restoration would be an effective way to reverse myocardial death and remodelling following myocardIAL infarction in humans.
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Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning
TL;DR: LR asymmetry determination depends on a very early differential ion flux created by H+/K+-ATPase activity, which randomized the sided pattern of asymmetrically expressed genes and induced organ heterotaxia.
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Inhibition of miR-25 improves cardiac contractility in the failing heart
Christine Wahlquist,Dongtak Jeong,Agustin Rojas-Muñoz,Changwon Kho,Ahyoung Lee,Shinichi Mitsuyama,Alain van Mil,Woo Jin Park,Joost P.G. Sluijter,Pieter A. Doevendans,Roger J. Hajjar,Mark Mercola +11 more
TL;DR: High-throughput functional screening of the human microRNAome reveals that increased expression of endogenous miR-25 contributes to declining cardiac function during heart failure and suggests that it might be targeted therapeutically to restore function.
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High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Arun Sharma,Paul W. Burridge,Paul W. Burridge,Wesley L. McKeithan,Wesley L. McKeithan,Ricardo Serrano,Praveen K. Shukla,Nazish Sayed,Jared M. Churko,Tomoya Kitani,Haodi Wu,Alexandra Holmström,Elena Matsa,Yuan Zhang,Anusha Kumar,Alice C. Fan,Juan C. del Álamo,Sean M. Wu,Javid Moslehi,Mark Mercola,Mark Mercola,Joseph C. Wu +21 more
TL;DR: In this article, the authors used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), generated from 11 healthy individuals and 2 patients receiving cancer treatment, to screen U.S. Food and Drug Administration-approved TKIs for cardiotoxicities by measuring alterations in Cardiomyocyte viability, contractility, electrophysiology, calcium handling, and signaling.