M
Mark Meuth
Researcher at University of Sheffield
Publications - 98
Citations - 12291
Mark Meuth is an academic researcher from University of Sheffield. The author has contributed to research in topics: Gene & Chinese hamster ovary cell. The author has an hindex of 50, co-authored 98 publications receiving 11515 citations. Previous affiliations of Mark Meuth include University of Cambridge & University of Utah.
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Journal ArticleDOI
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant,Nilklas Schultz,Huw D. Thomas,Kayan M. Parker,Dan Flower,Elena Lopez,Suzanne Kyle,Mark Meuth,Nicola J. Curtin,Thomas Helleday,Thomas Helleday +10 more
TL;DR: It is proposed that, in the absence of PARP1, spontaneous single-strand breaks collapse replication forks and trigger homologous recombination for repair and exploited in order to kill BRCA2-deficient tumours by PARP inhibition alone.
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An established pre-adipose cell line and its differentiation in culture
Howard Green,Mark Meuth +1 more
TL;DR: The conversion of 3T3-L1 from pre-adipose to adipose cells therefore involves a process of differentiation which can be studied under cell culture conditions.
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Mutator phenotypes in human colorectal carcinoma cell lines
TL;DR: The data suggest that the mutatw phenotypes in the colorectal carcinoma cell lines could be the consequence of mutator genes affecting different repair or error-avoidance pathways.
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Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer
James W.F. Catto,Saiful Miah,Helen C. Owen,Helen E. Bryant,Katie N. Myers,Ewa Dudziec,Stéphane Larré,Marta Milo,Ishtiaq Rehman,Derek J. Rosario,Erica di Martino,Margaret A. Knowles,Mark Meuth,Adrian L. Harris,Freddie C. Hamdy +14 more
TL;DR: It is found that altered microRNA expression is common in U CC and occurs early in tumorogenesis, and distinct microRNA alterations characterize UCC and target genes in a pathway-specific manner.
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Promoter Hypermethylation Is Associated With Tumor Location, Stage, and Subsequent Progression in Transitional Cell Carcinoma
James W.F. Catto,Abdel Rahmene Azzouzi,Ishtiaq Rehman,K. Feeley,Simon S. Cross,Najla Amira,Gaëlle Fromont,Mathilde Sibony,O. Cussenot,Mark Meuth,Freddie C. Hamdy +10 more
TL;DR: Methylation occurs commonly in urinary tract tumors, may affect carcinogenic mechanisms, and is a prognostic marker and a potential therapeutic target.