M
Mark N. Kirstein
Researcher at University of Minnesota
Publications - 59
Citations - 4676
Mark N. Kirstein is an academic researcher from University of Minnesota. The author has contributed to research in topics: Gemcitabine & Population. The author has an hindex of 23, co-authored 55 publications receiving 4385 citations. Previous affiliations of Mark N. Kirstein include St. Jude Children's Research Hospital & University of Mississippi Medical Center.
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Journal ArticleDOI
Fusion of a Kinase Gene, ALK, to a Nucleolar Protein Gene, NPM, in Non-Hodgkin's Lymphoma
Stephan W. Morris,Mark N. Kirstein,Marcus B. Valentine,KG Dittmer,KG Dittmer,David N. Shapiro,David N. Shapiro,D. L. Saltman,AT Look,AT Look +9 more
TL;DR: In the predicted hybrid protein, the amino terminus of nucleophosmin (NPM) is linked to the catalytic domain of anaplastic lymphoma kinase (ALK), and unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.
Journal ArticleDOI
ALK , the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
Stephan W. Morris,Clayton W. Naeve,Prasad Mathew,Payton L James,Mark N. Kirstein,Xiaoli Cui,David P. Witte,David P. Witte +7 more
TL;DR: Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin receptor subfamily of receptor tyrosine kinases that acquires transforming capability when truncated and fused to nucleophosmin (NPM) in the t(2;5) chromosomal rearrangement associated with non-Hodgkin's lymphoma, but further insights into its normal structure and function are lacking as discussed by the authors.
Journal Article
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
Yoneda-Kato N,A. T. Look,Mark N. Kirstein,Marcus B. Valentine,Susana C. Raimondi,Cohen Kj,Andrew J. Carroll,Stephan W. Morris +7 more
TL;DR: RNA-based polymerase chain reaction analysis revealed identical NPM-MLF1 mRNA fusions in each of the three t(3;5)-positive cases of AML examined, indicating that NPM trafficking signals direct MLF1 to an inappropriate cellular compartment in myeloid leukemia cells.
Journal ArticleDOI
Sequence correction [8]
Stephan W. Morris,Mark N. Kirstein,Marcus B. Valentine,KG Dittmer,D. N. Shapiro,A. T. Look,D. L. Saltman +6 more
Journal Article
Antitumor Activity of Temozolomide Combined with Irinotecan Is Partly Independent of O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Phenotypes in Xenograft Models
Peter J. Houghton,Clinton F. Stewart,Pamela J. Cheshire,Lois B. Richmond,Mark N. Kirstein,Catherine A. Poquette,Ming Tan,Henry S. Friedman,Thomas P. Brent +8 more
TL;DR: The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against eight independent xenografts, and the interaction appeared independent of tumor MGMT or mismatch repair phenotype, suggesting that the mechanism of synergy may be independent of O6-methylation by temozoomide.