M
Mark R. Brann
Researcher at University of Vermont
Publications - 39
Citations - 2631
Mark R. Brann is an academic researcher from University of Vermont. The author has contributed to research in topics: Receptor & Muscarinic acetylcholine receptor. The author has an hindex of 24, co-authored 39 publications receiving 2576 citations. Previous affiliations of Mark R. Brann include Laboratory of Molecular Biology & ACADIA Pharmaceuticals Inc..
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Journal ArticleDOI
Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.
Allan I. Levey,Steven M. Hersch,David B. Rye,Roger K. Sunahara,Hyman B. Niznik,Cheryl A. Kitt,Donald L. Price,Roberto Maggio,Mark R. Brann,Brian J. Ciliax +9 more
TL;DR: Results provide a morphological substrate for understanding the pre- and postsynaptic functions of the genetically defined D1 and D2 receptors in discrete neuronal circuits in mammalian brain.
Journal ArticleDOI
Dopamine D2 Receptor Dimers and Receptor-Blocking Peptides
Gordon Y.K. Ng,Brian F. O'Dowd,Samuel P. Lee,Hans T. Chung,Mark R. Brann,Philip Seeman,Susan R. George +6 more
TL;DR: In this paper, the transmembrane (TM) domains of the D2 receptor were mimicked by peptides derived from the TM domains, and the peptides were unable to dissociate dopamine D1 and serotonin 5-HT1B receptor dimers.
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Pharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cells.
TL;DR: The data demonstrate that a high throughput colorimetric assay performed in 96-well plates can be used to evaluate subtle differences the pharmacology of ligands for cloned muscarinic receptor subtypes.
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Phosphorylation and Palmitoylation of the Human D2L Dopamine Receptor in Sf9 Cells
TL;DR: The human D2long (D2L) dopamine receptor isoform is expressed and biochemically characterized using the baculovirus/Sf9 cell system with first direct evidence for D2L receptor phosphorylation and palmitoylation.
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Pharmacology of Muscarinic Receptor Subtypes Constitutively Activated by G Proteins
TL;DR: The results define the functional relationship between G protein levels and muscarinic receptor pharmacology and suggest regulation of G protein concentration may be an important means of controlling receptor activity in vivo.