Author
Mark S. Humayun
Other affiliations: Lawrence Livermore National Laboratory, Duke University, Johns Hopkins University ...read more
Bio: Mark S. Humayun is an academic researcher from University of Southern California. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 84, co-authored 636 publications receiving 26997 citations. Previous affiliations of Mark S. Humayun include Lawrence Livermore National Laboratory & Duke University.
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A retinal prosthesis was permanently implanted in the eye of a completely blind test subject and the subject was able to see perceptions of light (spots) on all 16 electrodes of the array.
875 citations
••
TL;DR: The 25-gauge transconjunctival sutureless vitrectomy system (TSV) was evaluated in vitro using balanced saline solution and porcine vitreous for several levels of aspiration power and bottle height.
639 citations
••
TL;DR: Experiments were conducted to study if electrical stimulation of the retinal surface can elicit visual sensation in individuals blind from end-stage retinitis pigmentosa (RP) or age-related macular degeneration (AMD).
616 citations
••
TL;DR: In this paper, the extent of preservation in the inner retina in retinitis pigmentosa (RP) was determined by counting cell nuclei in the outer nuclear, inner nuclear, and ganglion cell layers within thirty 100-μm intervals from the foveola to 1500μm eccentricity.
Abstract: Objective: To determine the extent of preservation in the inner retina in retinitis pigmentosa (RP). Methods: We analyzed sectioned maculae of 21 postmortem eyes with RP and 19 age-matched, normal, postmortem eyes. Eyes were divided into 2 groups: severe and moderate RP. Cell nuclei were counted in the outer nuclear, inner nuclear, and ganglion cell layers within thirty 100-μm intervals from the foveola to 1500-μm eccentricity. Results: Statistically significant (P≤.05) loss of both the outer nuclear and ganglion cell layers was present in the groups with moderate and severe RP when compared with the control groups. However, even in the group with severe RP, 30% of the ganglion cells were histologically intact. Similarly, 78% and 88% of the inner nuclear layer cells were preserved in the groups with severe and moderate RP, respectively. Different inheritance modes showed no statistically significant differences in any of the retinal layers. Conclusions: Despite a statistically significant (P≤.05) loss of cells found in all retinal layers, a large percentage of the inner retinal neurons remained histologically intact. Current experimental therapies, such as photoreceptor transplantation and implantation of a visual prosthesis, are based on the premise that some inner retinal neurons are preserved after death of photoreceptors in RP. Our observations support this assumption.
612 citations
••
University of Southern California1, Moorfields Eye Hospital2, Johns Hopkins University3, Manchester Royal Eye Hospital4, University of Pennsylvania5, University of California, San Francisco6, Massachusetts Eye and Ear Infirmary7, Wills Eye Institute8, Monterrey Institute of Technology and Higher Education9, Lighthouse International10, Columbia University11
TL;DR: The long-term safety results of Second Sight's retinal prosthesis system are acceptable, and most subjects with profound visual loss perform better on visual tasks with system than without it.
608 citations
Cited by
More filters
••
[...]
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
•
28,685 citations
••
31 Oct 2001
TL;DR: The American Society for Testing and Materials (ASTM) as mentioned in this paper is an independent organization devoted to the development of standards for testing and materials, and is a member of IEEE 802.11.
Abstract: The American Society for Testing and Materials (ASTM) is an independent organization devoted to the development of standards.
3,792 citations