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Mark S. Humayun

Bio: Mark S. Humayun is an academic researcher from University of Southern California. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 84, co-authored 636 publications receiving 26997 citations. Previous affiliations of Mark S. Humayun include Lawrence Livermore National Laboratory & Duke University.


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TL;DR: A retinal prosthesis was permanently implanted in the eye of a completely blind test subject and the subject was able to see perceptions of light (spots) on all 16 electrodes of the array.

875 citations

Journal ArticleDOI
TL;DR: The 25-gauge transconjunctival sutureless vitrectomy system (TSV) was evaluated in vitro using balanced saline solution and porcine vitreous for several levels of aspiration power and bottle height.

639 citations

Journal ArticleDOI
TL;DR: Experiments were conducted to study if electrical stimulation of the retinal surface can elicit visual sensation in individuals blind from end-stage retinitis pigmentosa (RP) or age-related macular degeneration (AMD).

616 citations

Journal ArticleDOI
TL;DR: In this paper, the extent of preservation in the inner retina in retinitis pigmentosa (RP) was determined by counting cell nuclei in the outer nuclear, inner nuclear, and ganglion cell layers within thirty 100-μm intervals from the foveola to 1500μm eccentricity.
Abstract: Objective: To determine the extent of preservation in the inner retina in retinitis pigmentosa (RP). Methods: We analyzed sectioned maculae of 21 postmortem eyes with RP and 19 age-matched, normal, postmortem eyes. Eyes were divided into 2 groups: severe and moderate RP. Cell nuclei were counted in the outer nuclear, inner nuclear, and ganglion cell layers within thirty 100-μm intervals from the foveola to 1500-μm eccentricity. Results: Statistically significant (P≤.05) loss of both the outer nuclear and ganglion cell layers was present in the groups with moderate and severe RP when compared with the control groups. However, even in the group with severe RP, 30% of the ganglion cells were histologically intact. Similarly, 78% and 88% of the inner nuclear layer cells were preserved in the groups with severe and moderate RP, respectively. Different inheritance modes showed no statistically significant differences in any of the retinal layers. Conclusions: Despite a statistically significant (P≤.05) loss of cells found in all retinal layers, a large percentage of the inner retinal neurons remained histologically intact. Current experimental therapies, such as photoreceptor transplantation and implantation of a visual prosthesis, are based on the premise that some inner retinal neurons are preserved after death of photoreceptors in RP. Our observations support this assumption.

612 citations


Cited by
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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

Reference EntryDOI
31 Oct 2001
TL;DR: The American Society for Testing and Materials (ASTM) as mentioned in this paper is an independent organization devoted to the development of standards for testing and materials, and is a member of IEEE 802.11.
Abstract: The American Society for Testing and Materials (ASTM) is an independent organization devoted to the development of standards.

3,792 citations

01 Jun 2005

3,154 citations