M
Mark W. Dewhirst
Researcher at Duke University
Publications - 809
Citations - 61940
Mark W. Dewhirst is an academic researcher from Duke University. The author has contributed to research in topics: Hyperthermia & Cancer. The author has an hindex of 116, co-authored 797 publications receiving 57525 citations. Previous affiliations of Mark W. Dewhirst include University of Arizona & Durham University.
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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao,Qiulian Wu,Roger E. McLendon,Yueling Hao,Qing Ming Shi,Anita B. Hjelmeland,Mark W. Dewhirst,Darell D. Bigner,Jeremy N. Rich +8 more
TL;DR: This work shows that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity, and suggests that CD133-positive tumour cells could be the source of tumour recurrence after radiation.
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Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Pierre Sonveaux,Frédérique Végran,Thies Schroeder,Melanie Wergin,Julien Verrax,Zahid N. Rabbani,Christophe De Saedeleer,Kelly M. Kennedy,Caroline Diepart,Bénédicte F. Jordan,Michael J. Kelley,Bernard Gallez,Miriam L. Wahl,Olivier Feron,Mark W. Dewhirst +14 more
TL;DR: In this paper, the authors identified monocarboxylate transporter 1 (MCT1) as the prominent path for lactate uptake by a human cervix squamous carcinoma cell line that preferentially utilized lactate for oxidative metabolism.
Journal Article
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.
David M. Brizel,Sean P. Scully,John M. Harrelson,Lester J. Layfield,Joseph M. Bean,Leonard R. Prosnitz,Mark W. Dewhirst +6 more
TL;DR: The 18-month actuarial disease-free survival was 70% for patients with tumor median oxygen pressure (pO2) values of >10 mm Hg but only 35% for those with median pO2 values of <10mm Hg (P=0.01); potential mechanisms and implications for clinical trial design are discussed.
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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
TL;DR: Tumor hypoxia adversely affected the prognosis of patients in this study and understanding of the mechanistic relationship between Hypoxia and treatment outcome will allow the development of new and rational treatment programs in the future.
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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
TL;DR: A constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit, both spatially and temporally, in the hypoxic environment of tumours.