M
Markus Rapedius
Researcher at University of Kiel
Publications - 41
Citations - 1527
Markus Rapedius is an academic researcher from University of Kiel. The author has contributed to research in topics: Gating & Ion channel. The author has an hindex of 20, co-authored 36 publications receiving 1329 citations. Previous affiliations of Markus Rapedius include University of Arizona & Schiller International University.
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Journal ArticleDOI
KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.
Markus Reichold,Anselm A. Zdebik,E Lieberer,Markus Rapedius,Katharina Schmidt,Sascha Bandulik,Christina Sterner,Ines Tegtmeier,David Penton,Thomas Baukrowitz,Sally-Anne Hulton,Ralph Witzgall,Bruria Ben-Zeev,Alexander J. Howie,Robert Kleta,Detlef Bockenhauer,Richard Warth +16 more
TL;DR: In summary, EAST mutations of KCNJ10 lead to impaired channel function and structural changes in distal convoluted tubules and the metabolic alkalosis present in patients carrying the R65P mutation possibly improves residual function of KC NJ10, which shows higher activity at alkaline pH.
Journal ArticleDOI
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
Marcus Schewe,Ehsan Nematian-Ardestani,Han Sun,Han Sun,Marianne Musinszki,Sönke Cordeiro,Giovanna Bucci,Bert L. de Groot,Stephen J. Tucker,Markus Rapedius,Thomas Baukrowitz +10 more
TL;DR: V voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter, providing insight into the functional plasticity of a K+-selective filter.
Journal ArticleDOI
The pore structure and gating mechanism of K2P channels: K2P channel gating
Paula L. Piechotta,Markus Rapedius,Phillip J. Stansfeld,Murali K. Bollepalli,Gunter Erhlich,Isabelle Andres-Enguix,Hariolf Fritzenschaft,Niels Decher,Mark S.P. Sansom,Stephen J. Tucker,Thomas Baukrowitz +10 more
TL;DR: In this paper, quaternary ammonium (QA) ions bind with high affinity deep within the pore of TREK-1 and have free access to their binding site before channel activation by intracellular pH or pressure.
Journal ArticleDOI
The pore structure and gating mechanism of K2P channels
Paula L. Piechotta,Markus Rapedius,Phillip J. Stansfeld,Murali K. Bollepalli,Gunter Ehrlich,Isabelle Andres-Enguix,Hariolf Fritzenschaft,Niels Decher,Mark S.P. Sansom,Stephen J. Tucker,Thomas Baukrowitz +10 more
TL;DR: It is reported that quaternary ammonium ions bind with high-affinity deep within the pore of TREK-1 and have free access to their binding site before channel activation by intracellular pH or pressure, demonstrating that, unlike most other K+ channels, the bundle-crossing gate in this K2P channel is constitutively open.
The Pore Structure and Gating Mechanism of K2P Channels
Paula L. Piechotta,Markus Rapedius,Phillip J. Stansfeld,Murali K. Bollepalli,Gunter Ehrlich,Isabelle Andres-Enguix,Hariolf Fritzenschaft,Niels Decher,Sansom,Stephen J. Tucker,Thomas Baukrowitz +10 more
TL;DR: It is reported that quaternary ammonium ions bind with high‐affinity deep within the pore of TREK‐1 and have free access to their binding site before channel activation by intracellular pH or pressure, demonstrating that, unlike most other K+ channels, the bundle‐crossing gate in this K2P channel is constitutively open.