M
Markus Stoffel
Researcher at University of Geneva
Publications - 667
Citations - 57263
Markus Stoffel is an academic researcher from University of Geneva. The author has contributed to research in topics: Climate change & Rockfall. The author has an hindex of 102, co-authored 620 publications receiving 50796 citations. Previous affiliations of Markus Stoffel include University of Zurich & Medical College of Wisconsin.
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Journal ArticleDOI
Combinatorial microRNA target predictions.
Azra Krek,Dominic Grün,Matthew N. Poy,Rachel Wolf,Lauren Rosenberg,Eric J Epstein,Philip MacMenamin,Isabelle da Piedade,Kristin C. Gunsalus,Markus Stoffel,Nikolaus Rajewsky +10 more
TL;DR: PicTar, a computational method for identifying common targets of micro RNAs, is presented and widespread coordinate control executed by microRNAs is suggested, thus providing evidence for coordinate microRNA control in mammals.
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Silencing of microRNAs in vivo with ‘antagomirs’
Jan Krützfeldt,Nikolaus Rajewsky,Ravi Braich,Kallanthottathil G. Rajeev,Thomas Tuschl,Muthiah Manoharan,Markus Stoffel +6 more
TL;DR: It is shown that a novel class of chemically engineered oligonucleotides, termed ‘antagomirs’, are efficient and specific silencers of endogenous miRNA levels in mice and may represent a therapeutic strategy for silencing miRNAs in disease.
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A pancreatic islet-specific microRNA regulates insulin secretion
Matthew N. Poy,Lena Eliasson,Jan Krützfeldt,Satoru Kuwajima,Xiaosong Ma,Patrick E. MacDonald,Sébastien Pfeffer,Thomas Tuschl,Nikolaus Rajewsky,P Rorsman,P Rorsman,Markus Stoffel +11 more
TL;DR: It is shown that overexpression of miR-375 suppressed glucose-induced insulin secretion, and conversely, inhibition of endogenous mi R-375 function enhanced insulin secretion and may constitute a novel pharmacological target for the treatment of diabetes.
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Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
Kazuya Yamagata,Hiroto Furuta,Naohisa Oda,Pamela J. Kaisaki,Stephan Menzel,Nancy J. Cox,Stefan S. Fajans,Stefano Signorini,Markus Stoffel,Graeme I. Bell +9 more
TL;DR: It is shown that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepatocyte nuclear factor-1α (HNF-1 α), which is encoded by the gene TCF1, which is a transcription factor that helps in the tissue-specific regulation of the expression of several liver genes.
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The state and fate of Himalayan glaciers
Tobias Bolch,Tobias Bolch,Anil V. Kulkarni,Andreas Kääb,Christian Huggel,Christian Huggel,Frank Paul,J G Cogley,Holger Frey,Holger Frey,Jeffrey S. Kargel,Koji Fujita,M. Scheel,M. Scheel,Samjwal Ratna Bajracharya,Markus Stoffel,Markus Stoffel +16 more
TL;DR: The contemporary evolution of glaciers in the Himalayan region is reviewed, including those of the less well sampled region of the Karakoram to the Northwest, in order to provide a current, comprehensive picture of how they are changing.