Márta Korbonits

TL;DR: The data suggest that ghrelin might have widespread physiological effects via different, partly unidentified, subtypes of the GHS-R in endocrine and non-endocrine tissues.

TL;DR: The updated understanding of the antigluconeogenic action of met formin in the liver and the implications of the discoveries of metformin targets for the treatment of diabetes mellitus and cancer are discussed.

TL;DR: Ghrelin is a brain-gut peptide with growth hormone-releasing and appetite-inducing activities as mentioned in this paper, which is mainly secreted from the stomach mucosa but it is also expressed widely in different tissues and therefore may have both endocrine and paracrine effects.

TL;DR: It is demonstrated that AMPK not only links the orexigenic effects of endocannabinoids and ghrelin in the hypothalamus but also their effects on the metabolism of peripheral tissues, which provides a mechanism for a number of their known actions, including the reduction in infarct size in the myocardium, an increase in adipose tissue, and stimulation of appetite.

TL;DR: A functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD) is shown and the link between hypoxia signals (via VHL) and mitochondrial signals ( via SDH) is mediated by HIF1α.