M
Martin A. Javors
Researcher at University of Texas Health Science Center at San Antonio
Publications - 166
Citations - 14331
Martin A. Javors is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Phosphatidylethanol & Internal medicine. The author has an hindex of 47, co-authored 158 publications receiving 12532 citations. Previous affiliations of Martin A. Javors include University of Texas at Austin & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison,Randy Strong,Zelton D Sharp,James F. Nelson,Clinton M. Astle,Kevin Flurkey,Nancy L. Nadon,J. Erby Wilkinson,Krystyna Frenkel,Christy S. Carter,Christy S. Carter,Marco Pahor,Marco Pahor,Martin A. Javors,Elizabeth Fernandez,Richard A. Miller +15 more
TL;DR: It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.
Journal ArticleDOI
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Richard A. Miller,Richard A. Miller,David E. Harrison,Clinton M. Astle,Joseph A. Baur,Angela R. Boyd,Rafael de Cabo,Elizabeth Fernandez,Kevin Flurkey,Martin A. Javors,James F. Nelson,Carlos J. Orihuela,Scott D. Pletcher,Zelton D Sharp,David A. Sinclair,Joseph W. Starnes,J. Erby Wilkinson,Nancy L. Nadon,Randy Strong +18 more
TL;DR: Evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target ofRapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
Remi-Martin Laberge,Yu Sun,Arturo V. Orjalo,Christopher K. Patil,Adam Freund,Lili Zhou,Samuel C. Curran,Albert R. Davalos,Kathleen A. Wilson-Edell,Su Liu,Chandani Limbad,Marco Demaria,Patrick Wai-Lun Li,Gene B. Hubbard,Yuji Ikeno,Martin A. Javors,Pierre Yves Desprez,Christopher C. Benz,Pankaj Kapahi,Peter S. Nelson,Judith Campisi +20 more
TL;DR: It is shown that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells, which might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
Journal ArticleDOI
Oral topiramate for treatment of alcohol dependence: a randomised controlled trial
Bankole A. Johnson,Nassima Ait-Daoud,Charles L. Bowden,Carlo C. DiClemente,John D. Roache,Kevin Lawson,Martin A. Javors,Jennie Z. Ma +7 more
TL;DR: Topiramate (up to 300 mg per day) is more efficacious than placebo as an adjunct to standardised medication compliance management in treatment of alcohol dependence.
Journal ArticleDOI
Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis
TL;DR: A low rate of turnover of several neurotransmitters supports the proposed hypothesis of a metabolic defect in PFS and suggests that the defect occurs at a neuroregulatory level.