M
Martin A. Schwartz
Researcher at Yale University
Publications - 363
Citations - 53835
Martin A. Schwartz is an academic researcher from Yale University. The author has contributed to research in topics: Integrin & Cell adhesion. The author has an hindex of 106, co-authored 341 publications receiving 49422 citations. Previous affiliations of Martin A. Schwartz include University of Missouri–Kansas City & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
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Cell adhesion: integrating cytoskeletal dynamics and cellular tension
TL;DR: Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.
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Integrins: Emerging Paradigms of Signal Transduction
TL;DR: Integrins receive signals from other receptors that lead to activation of ligand binding (inside-out signaling) and matrix assembly and activate intracellular signaling pathways that converse with pathways initiated by soluble ligands to regulate cell functions.
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Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton
TL;DR: The results show that ECM, cytoskeletal structures and soluble factors all contribute to regulation of Rho activity, and both cytochalasin D and colchicine trigger Rho activation despite their opposite effects on stress fibers and focal adhesions.
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The extracellular matrix as a cell survival factor.
TL;DR: The results suggest that in addition to regulating cell growth and differentiation, the ECM also functions as a survival factor for many cell types.