M
Martin Borggrefe
Researcher at Heidelberg University
Publications - 458
Citations - 15083
Martin Borggrefe is an academic researcher from Heidelberg University. The author has contributed to research in topics: Heart failure & Atrial fibrillation. The author has an hindex of 51, co-authored 458 publications receiving 12615 citations. Previous affiliations of Martin Borggrefe include University of Mannheim.
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Journal ArticleDOI
Loss-of-Function Mutations in the Cardiac Calcium Channel Underlie a New Clinical Entity Characterized by ST-Segment Elevation, Short QT Intervals, and Sudden Cardiac Death
Charles Antzelevitch,Guido D. Pollevick,Jonathan M. Cordeiro,Oscar Casis,Michael C. Sanguinetti,Yoshiyasu Aizawa,Alejandra Guerchicoff,Ryan Pfeiffer,Antonio Oliva,Bernd Wollnik,Philip Gelber,Elias P. Bonaros,Elena Burashnikov,Yuesheng Wu,John D. Sargent,Stefan Schickel,Ralf Oberheiden,Atul Bhatia,Li Fern Hsu,Michel Haïssaguerre,Rainer Schimpf,Martin Borggrefe,Christian Wolpert +22 more
TL;DR: This is the first report of loss-of-function mutations in genes encoding the cardiac L-type calcium channel to be associated with a familial sudden cardiac death syndrome in which a Brugada syndrome phenotype is combined with shorter-than-normal QT intervals.
Journal ArticleDOI
Long-Term Prognosis of Patients Diagnosed With Brugada Syndrome Results From the FINGER Brugada Syndrome Registry
Vincent Probst,Christian Veltmann,Lars Eckardt,Paola G. Meregalli,Fiorenzo Gaita,Hanno L. Tan,Dominique Babuty,Frederic Sacher,Carla Giustetto,Eric Schulze-Bahr,Martin Borggrefe,M. Haissaguerre,Philippe Mabo,H. Le Marec,Christian Wolpert,Arthur A.M. Wilde +15 more
TL;DR: In the largest series of Brugada syndrome patients thus far, event rates in asymptomatic patients were low and gender, familial history of SCD, inducibility of ventricular tachyarrhythmias during electrophysiological study, and the presence of an SCN5A mutation were not predictive of arrhythmic events.
Journal ArticleDOI
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death
Connie R. Bezzina,Julien Barc,Yuka Mizusawa,Carol Ann Remme,Jean-Baptiste Gourraud,Floriane Simonet,Floriane Simonet,Floriane Simonet,Arie O. Verkerk,Peter J. Schwartz,Lia Crotti,Federica Dagradi,Pascale Guicheney,Pascale Guicheney,Véronique Fressart,Véronique Fressart,Antoine Leenhardt,Antoine Leenhardt,Charles Antzelevitch,Susan Bartkowiak,Martin Borggrefe,Rainer Schimpf,Eric Schulze-Bahr,Sven Zumhagen,Elijah R. Behr,Rachel Bastiaenen,Jacob Tfelt-Hansen,Jacob Tfelt-Hansen,Morten S. Olesen,Morten S. Olesen,Stefan Kääb,Britt M. Beckmann,Peter Weeke,Hiroshi Watanabe,Naoto Endo,Tohru Minamino,Minoru Horie,Seiko Ohno,Kanae Hasegawa,Naomasa Makita,Akihiko Nogami,Wataru Shimizu,Takeshi Aiba,Philippe Froguel,Philippe Froguel,Philippe Froguel,Beverley Balkau,Beverley Balkau,Olivier Lantieri,Margherita Torchio,Cornelia Wiese,David Weber,Rianne Wolswinkel,Ruben Coronel,Bas J. Boukens,Stéphane Bézieau,Eric Charpentier,Eric Charpentier,Eric Charpentier,Stéphanie Chatel,Aurore Despres,Françoise Gros,Françoise Gros,Françoise Gros,Florence Kyndt,Simon Lecointe,Pierre Lindenbaum,Vincent Portero,Vincent Portero,Vincent Portero,Jade Violleau,Manfred Gessler,Hanno L. Tan,Dan M. Roden,Vincent M. Christoffels,Hervé Le Marec,Arthur A.M. Wilde,Vincent Probst,Jean-Jacques Schott,Christian Dina,Richard Redon +80 more
TL;DR: The association signals at SCN5A-SCN10A demonstrate that genetic polymorphisms modulating cardiac conduction can also influence susceptibility to cardiac arrhythmia and indicate that common genetic variation can have a strong impact on the predisposition to rare diseases.
Journal ArticleDOI
PexeLizumab for Acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: A randomized controlled trial
Paul W. Armstrong,N. Bett,David Brieger,D. Chew,R. Dick,A. Farshid,P Garrahy,B. Gunalingham,R. Hendriks,John D. Horowitz,Nigel Jepson,Jeffrey Lefkovits,S. Lo,Ian T. Meredith,G. Nelson,G. New,Ananth M. Prasan,J. Rankin,P. Thompson,S. Worthley,R. Yadav,Kurt Huber,Gerald Maurer,P. Siostrzonek,J. Boland,C. Covens,Walter Desmet,K. Dujardin,M. Vrolix,Christopher E. Buller,P. Klinke,C. Lazzam,Sohrab Lutchmedial,Mina Madan,Madhu K. Natarajan,François Reeves,J. Rodes Cabau,Barry Rose,Erick Schampaert,Pierre Theroux,Mouhieddin Traboulsi,John G. Webb,Robert C. Welsh,R. Zimmerman,M. Aschermann,M. Branny,T. Budesinsky,P. Cervinka,H. Frantisek,T. Frantisek,L. Groch,P. Kala,M. Ritcher,R. Rokyta,J. St'asek,R. Stipal,I. Varvarovsky,D. Zamanek,M. Zelizko,T. Toftegaard Nielsen,K. Rasmussen,P. RiisHansen,P. Thayssen,P. Beaufils,P. Geslin,Y. Gottwalles,H. Lebreton,H. LeMarec,Gilles Montalescot,G. Roul,Phillippe Gabriel Steg,C. Tronc,H. J. Berger,Martin Borggrefe,J. Brachmann,P. Braun,M. Buerke,H. R. Figulla,H. Guelker,G. Hasenfuss,T. Heitzer,Hubertus Heuer,E. Hoffman,S. Hoffmann,K. H. Kuck,Franz-Josef Neumann,J. Neuzner,M. Rau,G. Richardt,Heribert Schunkert,R. Stern,W. Von Schedit,P. C. Werner,R. Zahn,G. Binetti,E. Bramucci,G. Carosio,A. Manari,A. Marzocchi,M. Medda,G. Piovaccari,Alessandro Politi,L. Vignali,R. Violini,M. Zanchetta,R. Zanini,K. Marques,H. Otto Peels,T. Slagboom,P. C. Smits,Harry Suryapranata,M. J. Suttorp,M. Van-DerEnt,I. Crozier,G. Devlin,Sian E. Harding,Harvey D. White,G. Wilkins,M. Krzeminska-Pakula,K. Loboz-Grudzien,W. Ruźyllo,W. Tracz,M. Trusz-Gluza,M. Almeida,J. Correiada Cunha,P. Farto Abreu,L. Mourão,H. Pereira,L. Providencia,R. Vascoda Gama,A. Bertriu,C. Cuellas,E. Esplugas,E. Garcia Fernandez,X. Goicolea,J. M. Hernandez,C. Macaya,V. Mainar,Angel Martínez Sánchez,P. Erikksson,Stefan James,G. Olivercrona,C. M. Pripp,E. Camenzind,M Pfisterer,M. Pieper,Hans Rickli,R. Acheatel,A. Ahmad,A. Albirini,R. Allen,A. Amkieh,H. V. Anderson,J. Anderson,B. Armstrong,W. Asfour,T. Ayres,M. Azrin,Z. Baber,L. Barr,G. Barsness,J. Batty,Mahesh Bikkina,James C. Blankenship,Duncan J. Campbell,P. Caples,T. Carlson,John C. Chambers,H. Chandna,B. Cheek,J. Cheirif,A. Chu,H. Colfer,B. Crenshaw,S. David,A. DeFranco,J. Dehoya,J. Diez,G. Eaton,E. Eichhorn,M. El Shahawy,T. Farah,W. Felten,D. Fortuin,Malcolm T. Foster,D. S. Gantt,J. Gard,M. Ghali,R. Glaser,M. Greenberg,John H. Griffin,G. Hanovich,N. Hassinger,S. Heifetz,Timothy D. Henry,J. Hermiller,J. Hernandez,R. Hodson,M. Imburgia,B. Iteld,Z. Jafar,A. Jain,N. Jamal,G. Kang,Ronald P. Karlsberg,S. Khanal,S. Khoury,J. Kieval,Robert Kipperman,Robert Kipperman,B. Kluck,David F. Kong,E. Kosinski,M. Kozak,H. Kozman,P. Kraft,A. Labroo,P. Lai,N. Lakkis,G. Lane,B. Laretta,D. Lee,M. Leesar,J. Leggett,M. Levine,S. Lieberman,M. Lim,J. Luber,V. Marques,K. Marzo,J. McGarvey,G. McKendall,B. McLellan,M. Meengs,D. Mego,A. Mehra,J. A. Messenger,J. O. Messenger,M. Midei,Matthew R. Miller,David J. Moliterno,K. Momah,M. Mowdy,A. Nahhas,J. Navas,A. Niederman,T. Nygaard,William W. O'Neill,Kunal Patel,S. Pfau,V. Pompili,D. Purdy,B. Reddy,Alan Rees,J. Reiner,A. Riba,E. Rivera,David T. Roberts,A. Rosenblatt,W. Rowe,S. Rowley,D. Rubin,K. Saeian,Frank S. Saltiel,S. Sample,B. Sanchez,I. Sarembock,Jorge F. Saucedo,T. Schreiber,Ranjit Shah,M. Singh,J. Slater,R. Small,C. Staniloae,P. S. Sundram,L. Swenson,G. Symkoviak,K. Tam,A. Taussig,J. Thatcher,P. Tolerico,J. Trippi,S. Turk,K. Van Osdol,R. Vicari,A. Virmani,M. Warner,R. Webel,J. Wertheimer,G. Williams,Jonathan H. Williams,M. Winniford,D. Wohns,D. X.M. Zhao +293 more
TL;DR: In this large clinical trial of patients treated with primary PCI for STEMI, mortality was low and unaffected by administration of pexelizumab, and the composite end points of death, shock, or heart failure were similar.
Journal ArticleDOI
J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge.
Charles Antzelevitch,Gan-Xin Yan,Michael J. Ackerman,Martin Borggrefe,Domenico Corrado,Jihong Guo,Ihor Gussak,Can Hasdemir,Minoru Horie,Heikki V. Huikuri,Changsheng Ma,Hiroshi Morita,Gi-Byoung Nam,Frédéric Sacher,Wataru Shimizu,Sami Viskin,Arthur A.M. Wilde +16 more
TL;DR: The J-wave syndromes (JWSs) consisting of the Brugada syndrome (BrS) and early repolarization syndrome (ERS) have captured the interest of the cardiology community over the past 2 decades following the identification of BrS as a new clinical entity.