M
Martin Däumer
Researcher at University of Cologne
Publications - 30
Citations - 1346
Martin Däumer is an academic researcher from University of Cologne. The author has contributed to research in topics: Virus & Population. The author has an hindex of 17, co-authored 28 publications receiving 1278 citations. Previous affiliations of Martin Däumer include Swiss Institute of Bioinformatics.
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Journal ArticleDOI
Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes
Niko Beerenwinkel,Martin Däumer,Mark Oette,Klaus Korn,Daniel Hoffmann,Rolf Kaiser,Thomas Lengauer,Joachim Selbig,Hauke Walter +8 more
TL;DR: From a set of 650 matched genotype-phenotype pairs, regression models are constructed for the prediction of phenotypic drug resistance from genotypes and standardized measures of resistance are provided that can be calculated from the genotype and are comparable between drugs.
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Error correction of next-generation sequencing data and reliable estimation of HIV quasispecies
TL;DR: It is concluded that pyrosequencing can be used to investigate genetically diverse samples with high accuracy if technical errors are properly treated and probabilistic haplotype inference outperforms the counting-based calling method in both precision and recall.
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Computational methods for the design of effective therapies against drug resistant HIV strains
Niko Beerenwinkel,Tobias Sing,Thomas Lengauer,Jörg Rahnenführer,Kirsten Roomp,Igor Savenkov,Roman Fischer,Daniel Hoffmann,Joachim Selbig,Klaus Korn,Hauke Walter,Thomas Berg,Patrick Braun,Gerd Fätkenheuer,Mark Oette,Jürgen K. Rockstroh,Bernd Kupfer,Rolf Kaiser,Martin Däumer +18 more
TL;DR: Several computational methods are developed whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data.
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Estimating HIV Evolutionary Pathways and the Genetic Barrier to Drug Resistance
Niko Beerenwinkel,Martin Däumer,Tobias Sing,Jörg Rahnenführer,Thomas Lengauer,Joachim Selbig,Daniel Hoffmann,Rolf Kaiser +7 more
TL;DR: The genetic barrier is a useful tool for design of effective treatment strategies and mutagenetic trees provide a quantitative picture of the evolution of drug resistance.
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Reactivation of an occult hepatitis B virus escape mutant in an anti-HBs positive, anti-HBc negative lymphoma patient
Sabine Awerkiew,Martin Däumer,Marcel Reiser,Ulrike C. Wend,Herbert Pfister,Rolf Kaiser,Wulf R. Willems,Wolfram H. Gerlich +7 more
TL;DR: Reliable screening and monitoring of severely immunosuppressed patients for HBV should include, in addition to anti- HBc and HBsAg, anti-HBs and sensitive HBV DNA assays.