M
Martin E. Schwab
Researcher at University of Zurich
Publications - 414
Citations - 45078
Martin E. Schwab is an academic researcher from University of Zurich. The author has contributed to research in topics: Spinal cord & Myelin. The author has an hindex of 108, co-authored 401 publications receiving 42806 citations. Previous affiliations of Martin E. Schwab include ETH Zurich & University of Kansas.
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Journal ArticleDOI
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
M S Chen,A B Huber,M E van der Haar,Martin Frank,Lisa Schnell,Adrian Spillmann,Franziska Christ,Martin E. Schwab +7 more
TL;DR: Cl cloning of nogo A, the rat complementary DNA encoding NI-220/250 is reported, showing that Nogo-A is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity.
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Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors.
Lisa Schnell,Martin E. Schwab +1 more
TL;DR: The capacity for CNS axons to regenerate and elongate within differentiated CNS tissue after the neutralization of myelin-associated neurite growth inhibitors is demonstrated.
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Degeneration and regeneration of axons in the lesioned spinal cord
TL;DR: This review briefly summarizes the current knowledge on the mechanisms involved in degeneration and tissue loss and in axonal regeneration subsequent to spinal cord lesions, particularly in mammals and humans.
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The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats.
Florence M. Bareyre,Florence M. Bareyre,Martin Kerschensteiner,Martin Kerschensteiner,Olivier Raineteau,Thomas C. Mettenleiter,Oliver Weinmann,Martin E. Schwab +7 more
TL;DR: The anatomical basis of this recovery was investigated and it was found that after incomplete spinal cord injury in rats, transected hindlimb corticospinal tract axons sprouted into the cervical gray matter to contact short and long propriospinal neurons (PSNs).
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Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion.
TL;DR: In adult rats, injection of NT-3 (but not BDNF) into the lesioned spinal cord increases the regenerative sprouting of the transected CST, and application of an antibody that neutralizes myelin-associated neurite growth inhibitory proteins results in long-distance regeneration of CST fibres.