Martin Eberle

TL;DR: A broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared and it was revealed that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched.

TL;DR: A focused collection of organic synthesis reactions for computer-based molecule construction inspired by real-world chemistry and compiled in close collaboration with medicinal chemists to achieve high practical relevance is presented.

TL;DR: The results suggest that established synthesis resources are well suited to cover the known bioactivity-relevant chemical space and that there are plenty of unexplored regions accessible by these reactions, possibly providing valuable "low-hanging fruit" for hit discovery.

TL;DR: In this article, the authors present a set of compounds of formula (I), or a salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and R8 are specified organic redicals; and compositions containing them, processes for making them and their use as fungicides.

TL;DR: A simple and general ligation method for the preparation of linear and cyclic peptides, starting from peptide thioester, mainly p-chlorophenyl, precursors is reported, with inherent advantages of the low epimerization, reduced dimerization, use of mild reaction conditions, and elimination of superfluous coupling reagents.