M
Martin F. Bachmann
Researcher at University of Bern
Publications - 456
Citations - 37553
Martin F. Bachmann is an academic researcher from University of Bern. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 100, co-authored 415 publications receiving 34124 citations. Previous affiliations of Martin F. Bachmann include University of Toronto & Hoffmann-La Roche.
Papers
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Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
TL;DR: This Review discusses the approaches currently being used to optimize the delivery of antigens and enhance vaccine efficacy and focuses on vaccines that have all the properties of pathogens with the exception of causing disease.
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mTOR regulates memory CD8 T-cell differentiation
Koichi Araki,Alexandra P. Turner,Virginia O. Shaffer,Shivaprakash Gangappa,Susanne A. Keller,Martin F. Bachmann,Christian P. Larsen,Rafi Ahmed +7 more
TL;DR: It is shown that mTOR (mammalian target of rapamycin, also known as FRAP1) is a major regulator of memory CD8 T-cell differentiation, and in contrast to what was expected, the immunosuppressive drug Rapamycin has immunostimulatory effects on the generation of memoryCD8 T cells.
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Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Manfred Kopf,G. Le Gros,Martin F. Bachmann,Marinus C. Lamers,Horst Bluethmann,Georges Köhler +5 more
TL;DR: It is concluded that IL-4 is required for the generation of the Th2-derived cytokines and that immune responses dependent on these cytokines are impaired.
Journal ArticleDOI
Nanoparticles target distinct dendritic cell populations according to their size
TL;DR: Evidence that particle size determines the mechanism of trafficking to the LN is provided and it is shown that only small nanoparticles can specifically target LN‐resident cells.
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The influence of antigen organization on B cell responsiveness
Martin F. Bachmann,Urs Hoffmann Rohrer,Thomas M. Kündig,Kurt Bürki,Hans Hengartner,Rolf M. Zinkernagel +5 more
TL;DR: In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV -G (ind) present as self antigen but responded promptly to the same antigen presented in the highly organized form.