M
Martin Hewison
Researcher at University of Birmingham
Publications - 300
Citations - 30548
Martin Hewison is an academic researcher from University of Birmingham. The author has contributed to research in topics: Vitamin D and neurology & Calcitriol receptor. The author has an hindex of 86, co-authored 281 publications receiving 27502 citations. Previous affiliations of Martin Hewison include Cardiff University & Royal Victoria Infirmary.
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Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
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Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain
TL;DR: The distribution of the 1,25-dihydroxyvitamin D3 receptor (VDR), and 1α-hydroxylase (1α-OHase), the enzyme responsible for the formation of the active vitamin in the human brain, was reported for the first time.
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11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
Jeremy W. Tomlinson,Elizabeth A. Walker,Iwona J. Bujalska,Nicole Draper,Gareth G. Lavery,Mark S. Cooper,Martin Hewison,Paul M. Stewart +7 more
TL;DR: It is speculated that hexose-6-phosphate dehydrogenase activity and therefore reduced nicotinamide-adenine dinucleotide phosphate supply may be crucial in determining the directionality of 11beta-HSD1 activity.
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Update in Vitamin D
John S. Adams,Martin Hewison +1 more
TL;DR: This review attempts to provide some explanation for the rapid decline in vitamin D status in the United States; the adverse impact of vitamin D insufficiency on skeletal, infectious/inflammatory, and metabolic health in humans; and the therapeutic rationale and reliable means for vigorous supplementation of the authors' diets with vitamin D.
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Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase.
Daniel Zehnder,Rosemary Bland,Mary C. Williams,Robert W. McNinch,Alexander J. Howie,Paul M. Stewart,Martin Hewison +6 more
TL;DR: Further immunohistochemical and Western blot analyses are described that detail for the first time the extrarenal distribution of 1α-hydroxylase in both normal and diseased tissues.