M
Martin Leeb
Researcher at University of Vienna
Publications - 41
Citations - 3356
Martin Leeb is an academic researcher from University of Vienna. The author has contributed to research in topics: Gene & Embryonic stem cell. The author has an hindex of 17, co-authored 36 publications receiving 2962 citations. Previous affiliations of Martin Leeb include Wellcome Trust Centre for Stem Cell Research & University of Cambridge.
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Journal ArticleDOI
3D structures of individual mammalian genomes studied by single-cell Hi-C
Tim J. Stevens,Tim J. Stevens,David Lando,Srinjan Basu,Liam P Atkinson,Yang Cao,Steven F. Lee,Martin Leeb,Kai J. Wohlfahrt,Wayne Boucher,Aoife O’Shaughnessy-Kirwan,Julie Cramard,Andre J. Faure,Meryem Ralser,Enrique Blanco,Lluis Morey,Miriam Sansó,Matthieu Palayret,Ben Lehner,Ben Lehner,Ben Lehner,Luciano Di Croce,Luciano Di Croce,Luciano Di Croce,Anton Wutz,Brian Hendrich,Dave Klenerman,Ernest D. Laue +27 more
TL;DR: 3D structures of entire mammalian genomes are calculated using data from a new chromosome conformation capture procedure that allows genome folding to be examined at a scale of less than 100 kb, and chromosome structures to be validated.
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Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination
Ragnhild Eskeland,Martin Leeb,Graeme R. Grimes,Clémence Kress,Shelagh Boyle,Duncan Sproul,Nick Gilbert,Yuhong Fan,Arthur I. Skoultchi,Anton Wutz,Wendy A. Bickmore +10 more
TL;DR: It is suggested that Ring1B-mediated chromatin compaction acts to directly limit transcription in vivo and to restore a compact chromatin state and to repress Hox gene expression is not dependent on its histone ubiquitination activity.
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Polycomb complexes act redundantly to repress genomic repeats and genes
TL;DR: It is found that genomic repeats are Polycomb targets and show that, in the absence of Polycomb complexes, endogenous murine leukemia virus elements can mobilize, indicating a contribution of the Polycomb group system to the defense against parasitic DNA, and a potential role of genomic repeats in Polycomb-mediated gene regulation.
Journal ArticleDOI
Derivation of haploid embryonic stem cells from mouse embryos
Martin Leeb,Anton Wutz +1 more
TL;DR: Haploid mouse embryonic stem cells are described and their application in forward genetic screening is shown.
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Antibiotics: a shot in the arm.
TL;DR: The world's antibiotics are failing and drug companies have all but stopped developing new ones, so one plan to avert the crisis is examined.