M
Martin Schreiber
Researcher at Medical University of Vienna
Publications - 63
Citations - 6439
Martin Schreiber is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Breast cancer & Genotype. The author has an hindex of 34, co-authored 60 publications receiving 6073 citations. Previous affiliations of Martin Schreiber include Research Institute of Molecular Pathology & University of Vienna.
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Journal ArticleDOI
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Andreas Eger,Kirsten Aigner,Stefan Eugen Sonderegger,Brigitta Dampier,Susanne Oehler,Martin Schreiber,Geert Berx,Amparo Cano,Hartmut Beug,Roland Foisner +9 more
TL;DR: RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF 1 is a key player in late stage carcinogenesis.
Journal ArticleDOI
Regulation of cancer cell migration and bone metastasis by RANKL
D. Holstead Jones,Tomoki Nakashima,Otto Sanchez,Otto Sanchez,Ivona Kozieradzki,Ivona Kozieradzki,Svetlana V. Komarova,Ildiko Sarosi,Sean Morony,Evelyn Rubin,Renu Sarao,Carlo V. Hojilla,Vukoslav Komnenovic,Young-Yun Kong,Martin Schreiber,S. Jeffrey Dixon,Stephen M. Sims,Rama Khokha,Teiji Wada,Josef M. Penninger,Josef M. Penninger +20 more
TL;DR: It is shown that the cytokine RANKL (receptor activator of NF-κB ligand) triggers migration of human epithelial cancer cells and melanoma cells that express the receptor RANK.
Journal ArticleDOI
The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
Kirsten Aigner,Brigitta Dampier,L Descovich,Mario Mikula,Aneesa Sultan,Martin Schreiber,Wolfgang Mikulits,Thomas Brabletz,Dennis Strand,P Obrist,Wolfgang Sommergruber,Norbert Schweifer,Andreas Wernitznig,Hartmut Beug,Roland Foisner,Andreas Eger +15 more
TL;DR: The data show that ZEB1 represents a key player in pathologic EMTs associated with tumour progression, and downregulation in undifferentiated cancer cells by RNA interference was sufficient to upregulate expression of cell polarity genes on the RNA and protein level, to re-establish epithelial features and to impair cell motility in vitro.
Journal ArticleDOI
Control of cell cycle progression by c-Jun is p53 dependent
Martin Schreiber,Andrea Kolbus,Fabrice Piu,Fabrice Piu,Axel Szabowski,Uta Möhle-Steinlein,Jianmin Tian,Michael Karin,Peter Angel,Erwin F. Wagner +9 more
TL;DR: It is demonstrated that fibroblasts derived from c-jun-/- mouse fetuses exhibit a severe proliferation defect and undergo a prolonged crisis before spontaneous immortalization, and a mechanistic link between c-Jun-dependent mitogenic signaling and cell-cycle regulation is established.
Journal ArticleDOI
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
Kanaga Sabapathy,Yinling Hu,Tuula Kallunki,Martin Schreiber,Jean-Pierre David,Wolfram Jochum,Erwin F. Wagner,Michael Karin +7 more
TL;DR: JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptotic induced byAnti-Fas antibody, UVC or dexamethasone, and is not required for activation-induced cell death of mature T cells.