M
Martin Smieško
Researcher at University of Basel
Publications - 104
Citations - 2055
Martin Smieško is an academic researcher from University of Basel. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 20, co-authored 90 publications receiving 1658 citations. Previous affiliations of Martin Smieško include Mario Negri Institute for Pharmacological Research & Comenius University in Bratislava.
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FimH antagonists for the oral treatment of urinary tract infections: from design and synthesis to in vitro and in vivo evaluation.
Tobias Klein,Daniela Abgottspon,Matthias Wittwer,Said Rabbani,Janno Herold,Xiaohua Jiang,Simon Kleeb,Christine Lüthi,Meike Scharenberg,Jacqueline Bezençon,Erich Gubler,Lijuan Pang,Martin Smieško,Brian Cutting,Oliver Schwardt,Beat Ernst +15 more
TL;DR: The synthesis and the in vitro/in vivo evaluation of α-D-mannosides with the ability to block the bacteria/host cell interaction are described and the great potential for the effective treatment of urinary tract infections with a new class of orally available antiinfectives could be demonstrated.
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Potential Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 606 Million Compounds
TL;DR: A compound library of over 606 million compounds for binding at the recently solved crystal structure of the main protease (Mpro) of SARS-CoV-2 is screened, finding 12 purchasable compounds, with binding affinity to the target protease that is predicted to be more favorable than that of the cocrystallized peptidomimetic compound.
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VirtualToxLab - a platform for estimating the toxic potential of drugs, chemicals and natural products.
TL;DR: The VirtualToxLab is an in silico technology for estimating the toxic potential of drugs, chemicals and natural products by interactively analyzing the binding mode of a compound with its target protein(s) in real-time 3D.
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OpenVirtualToxLab—A platform for generating and exchanging in silico toxicity data
TL;DR: The VirtualToxLab is an in silico technology for estimating the toxic potential--endocrine and metabolic disruption, some aspects of carcinogenicity and cardiotoxicity--of drugs, chemicals and natural products by interactively analyzing the binding mode of a compound with its target protein(s) in real-time 3D.
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Design, synthesis and biological evaluation of mannosyl triazoles as FimH antagonists.
Oliver Schwardt,Said Rabbani,Margrit Hartmann,Daniela Abgottspon,Matthias Wittwer,Simon Kleeb,Adam Zalewski,Martin Smieško,Brian Cutting,Beat Ernst +9 more
TL;DR: To address the druglikeness of this new class of FimH antagonists, selected pharmacokinetic parameters, which are critical for oral bioavailability (lipophilicity, solubility, and membrane permeation), were determined.