scispace - formally typeset
Search or ask a question
Author

Martina Koneracka

Bio: Martina Koneracka is an academic researcher from Slovak Academy of Sciences. The author has contributed to research in topics: Magnetic nanoparticles & Liquid crystal. The author has an hindex of 25, co-authored 145 publications receiving 2115 citations. Previous affiliations of Martina Koneracka include Centre national de la recherche scientifique.


Papers
More filters
Journal ArticleDOI
TL;DR: The potential applications of magnetic particles in several biomedical and biotechnology fields are discussed and the binding of the proteins and enzymes to magnetic particles was confirmed.

175 citations

Journal ArticleDOI
TL;DR: The experimental results indicated soft anchoring in the case of spherical magnetic particles and rigid anchoring for rodlike and chainlike magnetic particles, with parallel initial orientation between the magnetic moments of the magnetic particle and director.
Abstract: In this work the 4-(trans- 4'-n -hexylcyclohexyl)-isothiocyanatobenzene (6CHBT) liquid crystal was doped with differently shaped magnetite nanoparticles. The structural changes were observed by capacitance measurements and showed significant influence of the shape and size of the magnetic particles on the magnetic Freedericksz transition. For the volume concentration phi= 2 x 10(-4) of the magnetic particles, the critical magnetic field was established for the pure liquid crystal, and for liquid crystals doped with spherical, chainlike, and rodlike magnetic particles. The influence of the magnetic field depends on the type of anchoring, which is characterized by the density of anchoring energy and by the initial orientation between the liquid crystal molecules and the magnetic moment of the magnetic particles. The experimental results indicated soft anchoring in the case of spherical magnetic particles and rigid anchoring in the case of rodlike and chainlike magnetic particles, with parallel initial orientation between the magnetic moments of the magnetic particles and director.

126 citations

Journal ArticleDOI
TL;DR: It is found that magnetic Fe(3)O(4) nanoparticles are able to interact with lysozyme amyloids in vitro leading to a reduction of the amyloid aggregates, thus promoting depolymerization and their non-risk exploitation in nanomedicine and nanodiagnostics.
Abstract: Peptide amyloid aggregation is a hallmark of several human pathologies termed amyloid diseases. We have investigated the effect of electrostatically stabilized magnetic nanoparticles of Fe(3)O(4) on the amyloid aggregation of lysozyme, as a prototypical amyloidogenic protein. Thioflavin T fluorescence assay and atomic force microscopy were used for monitoring the inhibiting and disassembly activity of magnetic nanoparticles of Fe(3)O(4). We have found that magnetic Fe(3)O(4) nanoparticles are able to interact with lysozyme amyloids in vitro leading to a reduction of the amyloid aggregates, thus promoting depolymerization; the studied nanoparticles also inhibit lysozyme amyloid aggregation. The ability to inhibit lysozyme amyloid formation and promote lysozyme amyloid disassembly exhibit concentration-dependent characteristics with IC50 = 0.65 mg ml(-1) and DC50 = 0.16 mg ml(-1) indicating that nanoparticles interfere with lysozyme aggregation already at stoichiometric concentrations. These features make Fe(3)O(4) nanoparticles of potential interest as therapeutic agents against amyloid diseases and their non-risk exploitation in nanomedicine and nanodiagnostics.

119 citations

Journal ArticleDOI
TL;DR: Several clinically important proteins and enzymes have been immobilised onto fine magnetic particles using carbodiimide as a coupling agent and the possible applications in biomedicine and biotechnology are discussed.
Abstract: Several clinically important proteins and enzymes (bovine serum albumin (BSA), glucose oxidase (GOD) (EC 1.1.3.4), streptokinase (EC 3.4.99.0), chymotrypsin (EC 3.4.21.1) and dispase (EC 3.4.24.3)), respectively, have been immobilised onto fine magnetic particles using carbodiimide as a coupling agent. The coupling reactions of these substances were carried out using various ratios of magnetic particles to protein, and different values of pH to determine the optimum conditions of immobilisation. The possible applications in biomedicine and biotechnology of this method of immobilisation are discussed.

103 citations

Journal ArticleDOI
TL;DR: In this article, the DC dielectric breakdown strength of magnetic fluids based on transformer oil TECHNOL US 4000, with different saturation magnetizations, was investigated in various orientations of external magnetic field.

65 citations


Cited by
More filters
Book ChapterDOI
TL;DR: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed and the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed.
Abstract: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.

2,815 citations

Journal ArticleDOI
TL;DR: Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,†.
Abstract: Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Universite ́ Paris-Sud XI, UMR CNRS 8612, Faculte ́ de Pharmacie, IFR 141, 5 rue Jean-Baptiste Cleḿent, F-92296 Chat̂enay-Malabry, France Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain ‡Pharmaceutical Sciences Department, Sanofi, 13 Quai Jules Guesdes, F-94403 Vitry-sur-Seine, France

1,705 citations

Journal ArticleDOI
TL;DR: This review covers recent advances in the development of SPions together with their possibilities and limitations from fabrication to application in drug delivery and the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes.

1,557 citations

Journal ArticleDOI
TL;DR: This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds.
Abstract: Proteins, through their unique and specific interactions with other macromolecules and inorganics, control structures and functions of all biological hard and soft tissues in organisms. Molecular biomimetics is an emerging field in which hybrid technologies are developed by using the tools of molecular biology and nanotechnology. Taking lessons from biology, polypeptides can now be genetically engineered to specifically bind to selected inorganic compounds for applications in nano- and biotechnology. This review discusses combinatorial biological protocols, that is, bacterial cell surface and phage-display technologies, in the selection of short sequences that have affinity to (noble) metals, semiconducting oxides and other technological compounds. These genetically engineered proteins for inorganics (GEPIs) can be used in the assembly of functional nanostructures. Based on the three fundamental principles of molecular recognition, self-assembly and DNA manipulation, we highlight successful uses of GEPI in nanotechnology.

1,533 citations